High Ratios of C20:4n-6/C20:5n-3 and Thromboxane B 2 /6-Keto-Prostaglandin F 1α in Placenta Are Potential Risk Contributors for Neural Tube Defects: A Case-Control Study in Shanxi Province, China.

Autor: Li K; Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China., Zhang X; The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.; Institute of Population Research/WHO Collaborating Center on Reproductive Health and Population Science, Peking University, Beijing, China., Pei L; Institute of Population Research/WHO Collaborating Center on Reproductive Health and Population Science, Peking University, Beijing, China., Chen G; Institute of Population Research/WHO Collaborating Center on Reproductive Health and Population Science, Peking University, Beijing, China., Liu J; Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center, Beijing, China., Wahlqvist ML; Fuli Research Institute, Zhejiang University, Hangzhou, China.; Monash Asia Institute and Department of Nutrition and Dietetics, Monash University, Melbourne, Australia., Zheng X; Institute of Population Research/WHO Collaborating Center on Reproductive Health and Population Science, Peking University, Beijing, China., Li D; Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.; Monash Asia Institute and Department of Nutrition and Dietetics, Monash University, Melbourne, Australia.
Jazyk: angličtina
Zdroj: Birth defects research [Birth Defects Res] 2017 May 01; Vol. 109 (8), pp. 550-563. Date of Electronic Publication: 2017 Mar 24.
DOI: 10.1002/bdr2.1003
Abstrakt: Background: Neural tube defects (NTDs) are severe congenital malformations. Folate supplementation can reduce the risk, but cannot prevent all NTDs, suggesting other reasons for folate-resistant NTDs. The present study assesses placental fatty acid composition, eicosanoids, and cytokines as risk factors for NTDs in a Chinese population with highly incident NTDs.
Methods: Seventy-seven aborted fetuses with NTDs during the third trimester were cases and 142 healthy newborns were controls. Placental fatty acid composition, eicosanoids, and cytokines were determined by standard methods.
Results: The placental C20:4n-6/C20:5n-3 and thromboxane B 2 (TXB 2 )/6-keto-prostaglandin F 1α (6-keto-PGF 1α ) ratios were significantly higher for cases than controls (p < 0.001 and 0.05, respectively). For the top versus the lowest tertiles of placental C20:4n-6/C20:5n-3 and TXB 2 /6-keto-PGF 1α , odds ratios for NTD occurrence were 3.79 (95% confidence interval, 1.60-8.96) (p for trend < 0.01) and 5.52 (95% confidence interval, 2.07-14.74) (p for trend < 0.001), respectively, adjusted for fetal sex as well as maternal age, occupation, parity, smoking, passive smoking, periconceptional folate supplementation, conception season, and tea drinking. The C20:4n-6/C20:5n-3 and TXB 2 /6-keto-PGF 1α ratios were positively correlated (r = 0.14; p < 0.05). The proportions of C18:2n-6, C18:3n-6, C20:3n-6, C18:3n-3, C20:3n-3, C20:5n-3, and C22:5n-3 were significantly lower in cases than controls, and all negatively associated with NTD occurrence (tertile-specific odds ratios); after adjustment for the potential confounders, these associations remained significant (p for trend < 0.05) except for C20:3n-3.
Conclusion: High placental ratios of C20:4n-6/C20:5n-3 and TXB 2 /6-keto-PGF 1α are risk factors for neural tube defects.Birth Defects Research 109:550-563, 2017.© 2017 Wiley Periodicals, Inc.
(© 2017 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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