| Autor: |
Dabsys SM; Departamento de Sustancias Vasoactivas, Facultad de Medicina, Universidad de Buenos Aires, Argentina., Balda MS, Pirola CJ, Finkielman S, Nahmod VE |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and experimental hypertension. Part A, Theory and practice [Clin Exp Hypertens A] 1988; Vol. 10 (4), pp. 605-15. |
| DOI: |
10.3109/10641968809033913 |
| Abstrakt: |
The bilateral destruction of the ventral noradrenergic pathway induced by 6-hydroxydopamine (6-OHDA) administration into the ventral pons led to an increase in arterial blood pressure (ABP) and norepinephrine depletion in the amygdaloid complex, nucleus accumbens, septal area and olfactory bulb. Specific angiotensin converting enzyme (ACE) activity was significantly increased only in the amygdaloid complex (Control: 4.56 +/- 0.95; Vehicle: 4.08 +/- 1.07; 6-OHDA: 11.76 +/- 1.84). A significant correlation between arterial blood pressure and specific ACE activity levels in the amygdaloid complex was observed (r: 0.775; p less than 0.002). These results suggest that an increase in specific ACE activity of the amygdaloid complex after norepinephrine depletion could play a role in the development of hypertension in this model. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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