Evaluation of the toxic effect of endocrine disruptor Bisphenol A (BPA) in the acute and chronic toxicity tests with Pomacea lineata gastropod.

Autor: de Andrade ALC; Departamento de Morfologia e Fisiologia Animal (DMFA), Universidade Federal Rural de Pernambuco, Av. Dom Manoel de Medeiros s/n, 52171-900, Dois Irmãos, Recife, PE, Brazil., Soares PRL; Departamento de Morfologia e Fisiologia Animal (DMFA), Universidade Federal Rural de Pernambuco, Av. Dom Manoel de Medeiros s/n, 52171-900, Dois Irmãos, Recife, PE, Brazil., da Silva SCBL; Departamento de Morfologia e Fisiologia Animal (DMFA), Universidade Federal Rural de Pernambuco, Av. Dom Manoel de Medeiros s/n, 52171-900, Dois Irmãos, Recife, PE, Brazil., da Silva MCG; Departamento de Morfologia e Fisiologia Animal (DMFA), Universidade Federal Rural de Pernambuco, Av. Dom Manoel de Medeiros s/n, 52171-900, Dois Irmãos, Recife, PE, Brazil., Santos TP; Departamento de Morfologia e Fisiologia Animal (DMFA), Universidade Federal Rural de Pernambuco, Av. Dom Manoel de Medeiros s/n, 52171-900, Dois Irmãos, Recife, PE, Brazil., Cadena MRS; Unidade Acadêmica de Serra Talhada (UAST), Universidade Federal Rural de Pernambuco, Avenida Gregório Ferraz Nogueira s/n, 56909-535, José Ramos, Serra Talhada, PE, Brazil., Soares PC; Departamento de Medicina Veterinária (DMV), Universidade Federal de Pernambuco (UFPE), Av. Dom Manoel de Medeiros s/n, 52171-900, Dois Irmãos, Recife, PE, Brazil., Cadena PG; Departamento de Morfologia e Fisiologia Animal (DMFA), Universidade Federal Rural de Pernambuco, Av. Dom Manoel de Medeiros s/n, 52171-900, Dois Irmãos, Recife, PE, Brazil. Electronic address: pabyton.cadena@ufrpe.br.
Jazyk: angličtina
Zdroj: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2017 Jul; Vol. 197, pp. 1-7. Date of Electronic Publication: 2017 Apr 06.
DOI: 10.1016/j.cbpc.2017.04.002
Abstrakt: Bisphenol A (BPA) is a plasticizer and a risk when it interacts with organisms, and can cause changes in the development and reproduction of them. This study aimed to evaluate the effects of BPA, by acute and chronic toxicity tests with neonates and adults of Pomacea lineata. Adults and neonates were divided into groups exposed to BPA (1-20mg/L), or 17β-estradiol (1mg/L) and control in the acute and chronic toxicity tests. Behavior, heart rate, reproduction and hemolymph biochemical analysis were measured. In the acute toxicity test, the 96-h LC 50 with adults was 11.09 and with neonates was 3.14mg/L. In this test, it was observed lethargic behavior and an increase of 77.6% of aspartate aminotransferase in the adults' hemolymph (p<0.05); and neonates' heart rate decreased 72.7% (p<0.05). In the chronic toxicity test, it was observed behaviors associated with reproduction, as Copulate, in the groups exposed to BPA. The results that were found in this study proved that BPA is a potentially toxic agent to Pomacea lineata according to biological parameters evaluated. These data contribute to the understanding of BPA toxic effects' in the aquatic invertebrates.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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