Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model.

Autor:	Camargo Hizume-Kunzler D; State University of Santa Catarina, Physical Therapy, Florianopolis, Brazil., Greiffo FR; Nove de Julho University - UNINOVE, Research, São Paulo, Brazil., Fortkamp B; State University of Santa Catarina, Physical Therapy, Florianopolis, Brazil., Ribeiro Freitas G; Universidade do Estado de Santa Catarina Centro de Ciencias da Departamento de Fisioterapia, Saude e do Esporte, Florianopolis, Brazil., Keller Nascimento J; Universidade do Estado de Santa Catarina Centro de Ciencias da Departamento de Fisioterapia, Saude e do Esporte, Florianopolis, Brazil., Regina Bruggemann T; School of Medicine of University of Sao Paulo, Internal Medicine, Sao Paulo, Brazil., Melo Avila L; State University of Santa Catarina, Physical Therapy, Florianopolis, Brazil., Perini A; Faculdade de Medicina da Universidade de São Paulo, Departamento de Clínica Médica, São Paulo, Brazil., Bobinski F; Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil., Duarte Silva M; Department of Biological Science, Federal University of Santa Catarina, Florianopolis, Brazil., Rocha Lapa F; Universidade do Contestado Campus Concordia, Ciências Biológicas, Concordia, Brazil., Paula Vieira R; Nove de Julho University (UNINOVE), Laboratory of Pulmonary and Exercise Immunology (LABPEI) and Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Sao Paulo, Brazil., Vargas Horewicz V; Universidade Federal de Santa Catarina, Departamento de Farmacologia, Florianopolis, Brazil., Soares Dos Santos AR; Universidade Federal de Santa Catarina, Departamento de Ciências Biológicas, Florianópolis, Brazil., Cattelan Bonorino K; Universidade Federal de Santa Catarina, Departamento de Ciências Biológicas, Florianópolis, Brazil.
Jazyk:	angličtina
Zdroj:	International journal of sports medicine [Int J Sports Med] 2017 Jun; Vol. 38 (6), pp. 473-480. Date of Electronic Publication: 2017 Apr 07.
DOI:	10.1055/s-0042-121638
Abstrakt:	Aerobic exercise (AE) reduces lung function decline and risk of exacerbations in asthmatic patients. However, the inflammatory lung response involved in exercise during the sensitization remains unclear. Therefore, we evaluated the effects of exercise for 2 weeks in an experimental model of sensitization and single ovalbumin-challenge. Mice were divided into 4 groups: mice non-sensitized and not submitted to exercise (Sedentary, n=10); mice non-sensitized and submitted to exercise (Exercise, n=10); mice sensitized and exposed to ovalbumin (OVA, n=10); and mice sensitized, submitted to exercise and exposed to OVA (OVA+Exercise, n=10). 24 h after the OVA/saline exposure, we counted inflammatory cells from bronchoalveolar fluid (BALF), lung levels of total IgE, IL-4, IL-5, IL-10 and IL-1ra, measurements of OVA-specific IgG1 and IgE, and VEGF and NOS-2 expression via western blotting. AE reduced cell counts from BALF in the OVA group (p<0.05), total IgE, IL-4 and IL-5 lung levels and OVA-specific IgE and IgG1 titers (p<0.05). There was an increase of NOS-2 expression, IL-10 and IL-1ra lung levels in the OVA groups (p<0.05). Our results showed that AE attenuated the acute lung inflammation, suggesting immunomodulatory properties on the sensitization process in the early phases of antigen presentation in asthma. Competing Interests: Conflict of interest: The authors have no conflict of interest to declare. (© Georg Thieme Verlag KG Stuttgart · New York.)
Databáze:	MEDLINE
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