Therapy of Canine Hyperlipidemia with Bezafibrate.

Autor: De Marco V; University of Santo Amaro, São Paulo, Brazil.; University of Guarulhos, São Paulo, Brazil., Noronha KSM; University of Guarulhos, São Paulo, Brazil., Casado TC; University of Guarulhos, São Paulo, Brazil., Nakandakare ER; Medicine School, University of São Paulo, São Paulo, Brazil., Florio JC; Veterinary Medicine School, University of São Paulo, São Paulo, Brazil., Santos EZ; University of Santo Amaro, São Paulo, Brazil., Gilor C; University of California, Davis, CA.
Jazyk: angličtina
Zdroj: Journal of veterinary internal medicine [J Vet Intern Med] 2017 May; Vol. 31 (3), pp. 717-722. Date of Electronic Publication: 2017 Apr 06.
DOI: 10.1111/jvim.14701
Abstrakt: Background: Bezafibrate (BZF) is effective in the treatment of hypertriglyceridemia in human patients, but there are no data on its use in dogs.
Objective: To assess the safety of BZF in hyperlipidemic dogs and its efficacy in decreasing serum triglyceride (TG) and cholesterol (CHO) concentrations.
Animals: Forty-six dogs, 26 females and 20 males, mean (±SD) age of 9 (±3) years, with TG ≥150 mg/dL (33 dogs also were hypercholesterolemic [>300 mg/dL]).
Methods: Prospective, uncontrolled clinical trial. Dogs were treated with bezafibrate once daily, using 200 mg tablets at a dosage of 4-10 mg/kg (depending on body weight). Serum TG and CHO concentrations and alanine aminotransferase (ALT) and creatine kinase (CK) activity before and after 30 days of treatment were compared.
Results: Sixteen dogs (34.8%) had primary hyperlipidemia, and 30 dogs (65.2%) had secondary hyperlipidemia (including spontaneous hyperadrenocorticism [41.3%, n = 19/46], chronic treatment with glucocorticoids [10.8%, n = 5/46], and hypothyroidism [15.2%, n = 7/46]). After 30 days, serum TG concentration normalized (<150 mg/dL) in 42 dogs (91.3%) and CHO concentration normalized (<270 mg/dL) in 22 of 33 dogs (66.7%). There was no difference in baseline TG concentration between the primary and secondary hyperlipidemia subgroups, but the decrease in TG concentration after treatment was greater in the primary hyperlipidemia subgroup. No adverse effects were observed, but ALT activity decreased significantly after 30 days of treatment.
Conclusions and Clinical Importance: Over 30 days, BZF was safe and effective in treatment of primary and secondary hyperlipidemia in dogs.
(Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
Databáze: MEDLINE
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