| Autor: |
Sauceda R; Department of Genetics and Molecular Biology, CINVESTAV-IPN, Mexico, D.F., Ocadiz R, Gutierrez AL, Salcedo M, Ortega V, Figueroa HH, Gariglio P |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research [Brain Res] 1988 Apr; Vol. 427 (2), pp. 123-32. |
| DOI: |
10.1016/0169-328x(88)90057-5 |
| Abstrakt: |
We have examined forty human brain tumors (neoplasias presenting an important incidence in Mexico), for cellular myc (c-myc), N-myc and N-ras proto-oncogene alterations. An elevated amplification and/or rearrangement of the oncogenes was detected in most samples (60% presenting alteration for c-myc, 54% for N-myc, 6% for N-ras and 60% for ras-related genes). The tumors were of different histological types and for some of them we detected either amplification and/or rearrangement of the oncogenes. We describe, for the first time, the alterations of two related genes (c-myc and N-myc) in the same tumor samples; in 64% of the analyzed samples, oncogene alterations were accompanied by enhanced expression of N-myc and ras-related genes. These results suggest an important role for c-myc, N-myc and N-ras oncogenes, in the development and progression of brain tumors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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