StrandAdvantage test for early-line and advanced-stage treatment decisions in solid tumors.

Autor: Sen M; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India.; Mazumdar-Shaw Center for Translational Research (MSCTR), Mazumdar-Shaw Medical Foundation, A-Block, 8th Floor #258/A, NHHealth City, Bangalore, India., Katragadda S; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Ravichandran A; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Deshpande G; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Parulekar M; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Nayanala S; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Vittal V; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Shen W; Strand Life Sciences, 12635 E. Montview Blvd., Suite 360, Aurora, Colorado, 80045., Phooi Nee Yong M; Strand Life Sciences, 12635 E. Montview Blvd., Suite 360, Aurora, Colorado, 80045., Jacob J; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Parchuru S; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India.; Mazumdar-Shaw Center for Translational Research (MSCTR), Mazumdar-Shaw Medical Foundation, A-Block, 8th Floor #258/A, NHHealth City, Bangalore, India., Dhanuskodi K; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India.; Mazumdar-Shaw Center for Translational Research (MSCTR), Mazumdar-Shaw Medical Foundation, A-Block, 8th Floor #258/A, NHHealth City, Bangalore, India., Eyring K; Strand Life Sciences, 12635 E. Montview Blvd., Suite 360, Aurora, Colorado, 80045., Agrawal P; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Agarwal S; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Shanmugam A; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Gupta S; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Vishwanath D; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India.; Mazumdar-Shaw Center for Translational Research (MSCTR), Mazumdar-Shaw Medical Foundation, A-Block, 8th Floor #258/A, NHHealth City, Bangalore, India., Kumari K; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India.; Mazumdar-Shaw Center for Translational Research (MSCTR), Mazumdar-Shaw Medical Foundation, A-Block, 8th Floor #258/A, NHHealth City, Bangalore, India., Hariharan AK; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India.; Mazumdar-Shaw Center for Translational Research (MSCTR), Mazumdar-Shaw Medical Foundation, A-Block, 8th Floor #258/A, NHHealth City, Bangalore, India., Balaji SA; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India.; Mazumdar-Shaw Center for Translational Research (MSCTR), Mazumdar-Shaw Medical Foundation, A-Block, 8th Floor #258/A, NHHealth City, Bangalore, India., Liang Q; Strand Life Sciences, 12635 E. Montview Blvd., Suite 360, Aurora, Colorado, 80045., Robolledo B; Strand Life Sciences, 12635 E. Montview Blvd., Suite 360, Aurora, Colorado, 80045., Gauribidanur Raghavendrachar V; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Oomer Farooque M; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Buresh CJ; ProPath LLC, Dallas, Texas., Ramamoorthy P; Strand Life Sciences, 12635 E. Montview Blvd., Suite 360, Aurora, Colorado, 80045., Bahadur U; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Subramanian K; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Hariharan R; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Veeramachaneni V; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Sankaran S; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India., Gupta V; From Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bangalore, India.; Mazumdar-Shaw Center for Translational Research (MSCTR), Mazumdar-Shaw Medical Foundation, A-Block, 8th Floor #258/A, NHHealth City, Bangalore, India.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2017 May; Vol. 6 (5), pp. 883-901. Date of Electronic Publication: 2017 Apr 03.
DOI: 10.1002/cam4.1037
Abstrakt: Comprehensive genetic profiling of tumors using next-generation sequencing (NGS) is gaining acceptance for guiding treatment decisions in cancer care. We designed a cancer profiling test combining both deep sequencing and immunohistochemistry (IHC) of relevant cancer targets to aid therapy choices in both standard-of-care (SOC) and advanced-stage treatments for solid tumors. The SOC report is provided in a short turnaround time for four tumors, namely lung, breast, colon, and melanoma, followed by an investigational report. For other tumor types, an investigational report is provided. The NGS assay reports single-nucleotide variants (SNVs), copy number variations (CNVs), and translocations in 152 cancer-related genes. The tissue-specific IHC tests include routine and less common markers associated with drugs used in SOC settings. We describe the standardization, validation, and clinical utility of the StrandAdvantage test (SA test) using more than 250 solid tumor formalin-fixed paraffin-embedded (FFPE) samples and control cell line samples. The NGS test showed high reproducibility and accuracy of >99%. The test provided relevant clinical information for SOC treatment as well as more information related to investigational options and clinical trials for >95% of advanced-stage patients. In conclusion, the SA test comprising a robust and accurate NGS assay combined with clinically relevant IHC tests can detect somatic changes of clinical significance for strategic cancer management in all the stages.
(© 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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