Timed Get Up and Go Test and Geriatric 8 Scores and the Association With (Chemo-)Radiation Therapy Noncompliance and Acute Toxicity in Elderly Cancer Patients.

Autor:	Middelburg JG; Radiotherapy, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: j.middelburg-vanrijn@erasmusmc.nl., Mast ME; Department of Radiotherapy, Haaglanden Medical Center, The Hague, The Netherlands., de Kroon M; Radiotherapy, Erasmus Medical Center, Rotterdam, The Netherlands., Jobsen JJ; Radiation Oncology, Medisch Spectrum Twente, Enschede, The Netherlands., Rozema T; Radiotherapy, Institute Verbeeten, Tilburg, The Netherlands., Maas H; Geriatrics, Tweesteden Hospital, Tilburg, The Netherlands., Baartman EA; Radiotherapy, Erasmus Medical Center, Rotterdam, The Netherlands., Geijsen D; Radiotherapy, Academic Medical Center, Amsterdam, The Netherlands., van der Leest AH; Radiotherapy, University Medical Center Groningen, Groningen, The Netherlands., van den Bongard DJ; Department of Radiotherapy, University Medical Centre, Utrecht, The Netherlands., van Loon J; Department of Radiation Oncology (Maastro Clinic), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands., Budiharto T; Department of Radiotherapy, Catharina Ziekenhuis, Eindhoven, The Netherlands., Coebergh JW; Public Health, Erasmus Medical Center, Rotterdam, The Netherlands., Aarts MJ; Netherlands Cancer Registry, Netherlands Comprehensive Cancer Organization, Utrecht, The Netherlands., Struikmans H; Department of Radiotherapy, Haaglanden Medical Center, The Hague, The Netherlands.
Jazyk:	angličtina
Zdroj:	International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2017 Jul 15; Vol. 98 (4), pp. 843-849. Date of Electronic Publication: 2017 Jan 29.
DOI:	10.1016/j.ijrobp.2017.01.211
Abstrakt:	Purpose: To investigate whether the Geriatric 8 (G8) and the Timed Get Up and Go Test (TGUGT) and clinical and demographic patient characteristics were associated with acute toxicity of radiation therapy and noncompliance in elderly cancer patients being irradiated with curative intent. Methods and Materials: Patients were eligible if aged ≥65 years and diagnosed with breast, non-small cell lung, prostate, head and neck, rectal, or esophageal cancer, and were referred for curative radiation therapy. We recorded acute toxicity and noncompliance and identified potential predictors, including the G8 and TGUGT. Results: We investigated 402 patients with a median age of 72 years (range, 65-96 years). According to the G8, 44.4% of the patients were frail. Toxicity grade ≥3 was observed in 22% of patients who were frail according to the G8 and 9.1% of patients who were not frail. The difference was 13% (confidence interval 5.2%-20%; P=.0006). According to the TGUGT 18.8% of the patients were frail; 21% of the frail according to the TGUGT developed toxicity grade ≥3, compared with 13% who were not frail. The difference was 7.3% (confidence interval -2.7% to 17%; P=.11). Overall compliance was 95%. Toxicity was most strongly associated with type of primary tumor, chemotherapy, age, and World Health Organization performance status. Compliance was associated with type of primary tumor and age. Conclusions: The usefulness of the TGUGT and G8 score in daily practice seems to be limited. Type of primary tumor, chemoradiotherapy, age, and World Health Organization performance status were more strongly associated with acute toxicity. Only chemoradiotherapy and age were associated with noncompliance. Overall the compliance was very high. To allow better-informed treatment decisions, a more accurate prediction of toxicity is desirable. (Copyright © 2017. Published by Elsevier Inc.)
Databáze:	MEDLINE
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