Immunological implications of bovine leukemia virus infection.

Autor: Blagitz MG; Veterinary Clinical Immunology Research Group, Department of Clinical Science, Faculty of Veterinary Medicine and Animal Sciences, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universitária, São Paulo 05508-270, Brazil., Souza FN; Veterinary Clinical Immunology Research Group, Department of Clinical Science, Faculty of Veterinary Medicine and Animal Sciences, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universitária, São Paulo 05508-270, Brazil. Electronic address: nogueirasouza@usp.br., Batista CF; Veterinary Clinical Immunology Research Group, Department of Clinical Science, Faculty of Veterinary Medicine and Animal Sciences, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universitária, São Paulo 05508-270, Brazil., Azevedo LFF; Veterinary Clinical Immunology Research Group, Department of Clinical Science, Faculty of Veterinary Medicine and Animal Sciences, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universitária, São Paulo 05508-270, Brazil., Sanchez EMR; Institute of Tropical Medicine, University of São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 470, São Paulo 05403-000, Brazil., Diniz SA; Department of Preventive Veterinary Medicine, Veterinary School, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-010, Brazil., Silva MX; Department of Preventive Veterinary Medicine, Veterinary School, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-010, Brazil., Haddad JP; Department of Preventive Veterinary Medicine, Veterinary School, Federal University of Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte 31270-010, Brazil., Della Libera AMMP; Veterinary Clinical Immunology Research Group, Department of Clinical Science, Faculty of Veterinary Medicine and Animal Sciences, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universitária, São Paulo 05508-270, Brazil.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2017 Oct; Vol. 114, pp. 109-116. Date of Electronic Publication: 2017 Mar 24.
DOI: 10.1016/j.rvsc.2017.03.012
Abstrakt: This study examined neutrophil and monocyte functions and the blood lymphocyte profile of naturally BLV-infected cows with or without persistent lymphocytosis (PL). The percentage of neutrophils and monocytes that phagocytosed Staphylococcus aureus was lower in BLV-infected dairy cows, particularly those with PL. The relative percentage of CD44 + monocytes and neutrophils and CD11b expression by neutrophils was also lower in BLV-infected dairy cows with PL. A correlation between the percentage of CD11b + neutrophils and that produced reactive oxygen species (ROS) was found. Furthermore, the percentage of CD44 + monocytes was positively correlated with the percentage of monocytes that phagocytosed S. aureus and the same phenomenon was observed for neutrophils. In BLV-infected dairy cows, particularly those with PL, inhibition of monocyte and neutrophil apoptosis was observed. Additionally, the percentage of neutrophils producing ROS was lower in BLV-infected cows with PL, in contrast to higher intensity of intracellular production of ROS by monocytes. The result from the lymphocyte immunophenotyping of BLV-infected cows with PL was an increase in B cells, mainly B CD5 + CD11b + , due to the apoptosis inhibition. In conclusion, this study provides novel insight into the implications of BLV infection for cattle, which can include the dysfunction of blood monocytes and neutrophils.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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