| Autor: |
Segiet OA; a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland., Mielańczyk Ł; a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland., Piecuch A; a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland., Michalski M; a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland., Tyczyński S; b Department of General and Endocrine Surgery , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland., Brzozowa-Zasada M; a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland., Deska M; b Department of General and Endocrine Surgery , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland., Wojnicz R; a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland. |
| Abstrakt: |
Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. This review paper presents the role of apoptosis in PHPT. The comparison of the expression of Fas, TRAIL, BCL-2 family members, p53 in MGD, PA, and PC, among others, was described. The expression of described factors varies among proliferative lesions of parathyroid gland; therefore, these could serve as additional markers to assist in the diagnosis. |
