| Autor: |
Li J; Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China., Wei MM, Fei GJ, Feng YL, Yang H, Li Y, Lyu G, Shu HJ, Qian JM |
| Jazyk: |
čínština |
| Zdroj: |
Zhonghua nei ke za zhi [Zhonghua Nei Ke Za Zhi] 2017 Apr 01; Vol. 56 (4), pp. 279-283. |
| DOI: |
10.3760/cma.j.issn.0578-1426.2017.04.008 |
| Abstrakt: |
Objective: To clarify the efficacy and safety of cyclosporine A (CsA) as salvage therapy in patients with severe active ulcerative colitis (UC) and refractory to steroids. Methods: A total of 24 severe active UC patients refractory to steroids and hospitalized from 2006 to 2012, were retrospectively enrolled.Data including demographic features, clinical manifestations, laboratory tests and medications were collected. Results: CsA was effective in 15(62.5%) patients, who did not receive colectomy during 12-week administration. This regimen was tolerable in most patients.Twelve (50.0%) patients reported 16 adverse events, but only one patient withdrew CsA due to intolerance.The rates of adverse events in initial intravenous CsA including 4 mg·kg(-1)·d(-1,) 3 mg·kg(-1)·d(-1) and 2 mg·kg(-1)·d(-1) were 2/2, 9/17 and 1/5 respectively.Responders had higher white blood cell count compared with non-responders ( P = 0.045). Conclusions: CsA could be an effective alternative regimen to colectomy in severe active UC patients who are refractory to steroids. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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