90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model.

Autor:	Leite CA; Universidade Federal de São Paulo, Brazil., Bertoncello NS; Universidade Federal de São Paulo, Brazil., Watanabe IK; Universidade Federal de São Paulo, Brazil., Fernandes FB; Universidade Federal de São Paulo, Brazil., Andrade MC; Universidade Federal de São Paulo, Brazil., Ronchi FA; Universidade Federal de São Paulo, Brazil., Arita DY; Universidade Federal de São Paulo, Brazil., Marcondes FK; Universidade Estadual de Campinas, Brazil., Cunha TS; Universidade Federal de São Paulo, Brazil., Casarini DE; Universidade Federal de São Paulo, Brazil.
Jazyk:	Portuguese; English
Zdroj:	Jornal brasileiro de nefrologia [J Bras Nefrol] 2017 Mar; Vol. 39 (1), pp. 11-14.
DOI:	10.5935/0101-2800.20170002
Abstrakt:	Introduction: Hypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition. Objective: The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE. Methods: To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham. Results and Discussion: Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery. Conclusion: Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration.
Databáze:	MEDLINE
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