Osteoporosis and autophagy: What is the relationship?

Autor: Florencio-Silva R; PhD, Postdoctoral Student, Department of Morphology and Genetics, Division of Histology and Structural Biology, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil., Sasso GR; PhD, Postdoctoral Student, Department of Gynecology, Unifesp, São Paulo, SP, Brazil., Simões MJ; Full Professor of the Department of Morphology and Genetics, Division of Histology and Structural Biology, Unifesp, São Paulo, SP, Brazil., Simões RS; PhD, MD, Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil., Baracat MC; MSc Student, MD, Department of Obstetrics and Gynecology, FMUSP, São Paulo, SP, Brazil., Sasso-Cerri E; PhD, Adjunct Professor (Habilitation: BR. Livre-docente) of the Department of Morphology, Laboratory of Histology and Embryology, Faculty of Dentistry of Araraquara, Universidade Estadual Paulista (Unesp), Araraquara, SP, Brazil., Cerri PS; PhD, Adjunct Professor (Habilitation: BR. Livre-docente) of the Department of Morphology, Laboratory of Histology and Embryology, Faculty of Dentistry of Araraquara, Universidade Estadual Paulista (Unesp), Araraquara, SP, Brazil.
Jazyk: angličtina
Zdroj: Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2017 Feb; Vol. 63 (2), pp. 173-179.
DOI: 10.1590/1806-9282.63.02.173
Abstrakt: Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.
Databáze: MEDLINE
Externí odkaz: