Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: a Brazilian cohort.

Autor: Figueiredo ACC; Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 373, CCS, Bloco J, 2° andar, Cidade Universitária-Ilha do Fundão, Rio de Janeiro, 21941-902, Brazil., Cocate PG; Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 373, CCS, Bloco J, 2° andar, Cidade Universitária-Ilha do Fundão, Rio de Janeiro, 21941-902, Brazil., Adegboye ARA; Division of Nutrition, Food and Public Health, Department of Life Science, University of Westminster, London, UK., Franco-Sena AB; Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 373, CCS, Bloco J, 2° andar, Cidade Universitária-Ilha do Fundão, Rio de Janeiro, 21941-902, Brazil.; Department of Social Nutrition, Emília de Jesus Ferreira Nutrition School, Fluminense Federal University, Niteroi, Brazil., Farias DR; Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 373, CCS, Bloco J, 2° andar, Cidade Universitária-Ilha do Fundão, Rio de Janeiro, 21941-902, Brazil.; Graduate Program in Nutrition, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Rio de Janeiro, Brazil., de Castro MBT; Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 373, CCS, Bloco J, 2° andar, Cidade Universitária-Ilha do Fundão, Rio de Janeiro, 21941-902, Brazil.; Graduate Program in Nutrition, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Rio de Janeiro, Brazil., Brito A; USDA, ARS, Western Human Nutrition Research Center, University of California, Davis, USA., Allen LH; USDA, ARS, Western Human Nutrition Research Center, University of California, Davis, USA., Mokhtar RR; School of Medicine, Boston University , Boston, USA., Holick MF; School of Medicine, Boston University , Boston, USA., Kac G; Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 373, CCS, Bloco J, 2° andar, Cidade Universitária-Ilha do Fundão, Rio de Janeiro, 21941-902, Brazil. gilberto.kac@gmail.com.; Graduate Program in Nutrition, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Rio de Janeiro, Brazil. gilberto.kac@gmail.com.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2018 Apr; Vol. 57 (3), pp. 1059-1072. Date of Electronic Publication: 2017 Mar 28.
DOI: 10.1007/s00394-017-1389-z
Abstrakt: Purpose: To characterize the physiological changes in 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH) 2 D] throughout pregnancy.
Methods: Prospective cohort of 229 apparently healthy pregnant women followed at 5th-13th, 20th-26th, and 30th-36th gestational weeks. 25(OH)D and 1,25(OH) 2 D concentrations were measured by LC-MS/MS. Statistical analyses included longitudinal linear mixed-effects models adjusted for parity, season, education, self-reported skin color, and pre-pregnancy BMI. Vitamin D status was defined based on 25(OH)D concentrations according to the Endocrine Society Practice Guideline and Institute of Medicine (IOM) for adults.
Results: The prevalence of 25(OH)D <75 nmol/L was 70.4, 41.0, and 33.9%; the prevalence of 25(OH)D <50 nmol/L was 16.1, 11.2, and 10.2%; and the prevalence of 25(OH)D <30 nmol/L was 2, 0, and 0.6%, at the first, second, and third trimesters, respectively. Unadjusted analysis showed an increase in 25(OH)D (β = 0.869; 95% CI 0.723-1.014; P < 0.001) and 1,25(OH) 2 D (β = 3.878; 95% CI 3.136-4.620; P < 0.001) throughout pregnancy. Multiple adjusted analyses showed that women who started the study in winter (P < 0.001), spring (P < 0.001), or autumn (P = 0.028) presented a longitudinal increase in 25(OH)D concentrations, while women that started during summer did not. Increase of 1,25(OH) 2 D concentrations over time in women with insufficient vitamin D (50-75 nmol/L) at baseline was higher compared to women with sufficient vitamin D (≥75 nmol/L) (P = 0.006).
Conclusions: The prevalence of vitamin D inadequacy varied significantly according to the adopted criteria. There was a seasonal variation of 25(OH)D during pregnancy. The women with insufficient vitamin D status present greater longitudinal increases in the concentrations of 1,25(OH) 2 D in comparison to women with sufficiency.
Databáze: MEDLINE
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