Screening for Celiac Disease: US Preventive Services Task Force Recommendation Statement.

Autor:	Bibbins-Domingo K; University of California, San Francisco., Grossman DC; Group Health Research Institute, Seattle, Washington., Curry SJ; University of Iowa, Iowa City., Barry MJ; Harvard Medical School, Boston, Massachusetts., Davidson KW; Columbia University, New York, New York., Doubeni CA; University of Pennsylvania, Philadelphia., Ebell M; University of Georgia, Athens., Epling JW Jr; Virginia Tech Carilion School of Medicine, Roanoke., Herzstein J; Independent consultant, Washington, DC., Kemper AR; Duke University, Durham, North Carolina., Krist AH; Fairfax Family Practice Residency, Fairfax, Virginia12Virginia Commonwealth University, Richmond., Kurth AE; Yale University, New Haven, Connecticut., Landefeld CS; University of Alabama at Birmingham., Mangione CM; University of California, Los Angeles., Phipps MG; Brown University, Providence, Rhode Island., Silverstein M; Boston University, Boston, Massachusetts., Simon MA; Northwestern University, Evanston, Illinois., Tseng CW; University of Hawaii, Manoa.
Jazyk:	angličtina
Zdroj:	JAMA [JAMA] 2017 Mar 28; Vol. 317 (12), pp. 1252-1257.
DOI:	10.1001/jama.2017.1462
Abstrakt:	Importance: Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye, and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine. Objective: To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac disease. Evidence Review: The USPSTF reviewed the evidence on the accuracy of screening in asymptomatic adults, adolescents, and children; the potential benefits and harms of screening vs not screening and targeted vs universal screening; and the benefits and harms of treatment of screen-detected celiac disease. The USPSTF also reviewed contextual information on the prevalence of celiac disease among patients without obvious symptoms and the natural history of subclinical celiac disease. Findings: The USPSTF found inadequate evidence on the accuracy of screening for celiac disease, the potential benefits and harms of screening vs not screening or targeted vs universal screening, and the potential benefits and harms of treatment of screen-detected celiac disease. Conclusions and Recommendation: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for celiac disease in asymptomatic persons. (I statement).
Databáze:	MEDLINE
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