Milk Fat Globule Membrane Supplementation in Formula Modulates the Neonatal Gut Microbiome and Normalizes Intestinal Development.

Autor: Bhinder G; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Allaire JM; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Garcia C; Nutrition and Metabolism Research Program, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Lau JT; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Chan JM; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Ryz NR; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Bosman ES; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Graef FA; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Crowley SM; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Celiberto LS; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Berkmann JC; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Dyer RA; Nutrition and Metabolism Research Program, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Jacobson K; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Surette MG; Department of Medicine, McMaster University, Hamilton, ON, Canada., Innis SM; Nutrition and Metabolism Research Program, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada., Vallance BA; Division of Gastroenterology, Department of Pediatrics, BC Children's Hospital and the University of British Columbia, Vancouver, BC, Canada.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2017 Mar 28; Vol. 7, pp. 45274. Date of Electronic Publication: 2017 Mar 28.
DOI: 10.1038/srep45274
Abstrakt: Breast milk has many beneficial properties and unusual characteristics including a unique fat component, termed milk fat globule membrane (MFGM). While breast milk yields important developmental benefits, there are situations where it is unavailable resulting in a need for formula feeding. Most formulas do not contain MFGM, but derive their lipids from vegetable sources, which differ greatly in size and composition. Here we tested the effects of MFGM supplementation on intestinal development and the microbiome as well as its potential to protect against Clostridium difficile induced colitis. The pup-in-a-cup model was used to deliver either control or MFGM supplemented formula to rats from 5 to 15 days of age; with mother's milk (MM) reared animals used as controls. While CTL formula yielded significant deficits in intestinal development as compared to MM littermates, addition of MFGM to formula restored intestinal growth, Paneth and goblet cell numbers, and tight junction protein patterns to that of MM pups. Moreover, the gut microbiota of MFGM and MM pups displayed greater similarities than CTL, and proved protective against C. difficile toxin induced inflammation. Our study thus demonstrates that addition of MFGM to formula promotes development of the intestinal epithelium and microbiome and protects against inflammation.
Databáze: MEDLINE
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