Effect of Nigella sativa seed administration on prevention of febrile neutropenia during chemotherapy among children with brain tumors.

Autor: Mousa HFM; Department of Nutrition, High Institution of Public Health, Alexandria University, Alexandria, Egypt. drheba_fmoussa@yahoo.com.; Buraidah, Al-Qassim, Saudi Arabia. drheba_fmoussa@yahoo.com., Abd-El-Fatah NK; Department of Nutrition, High Institution of Public Health, Alexandria University, Alexandria, Egypt., Darwish OA; Department of Nutrition, High Institution of Public Health, Alexandria University, Alexandria, Egypt., Shehata SF; Department of Biostatistics, High Institute of Public Health, Alexandria University, Alexandria, Egypt., Fadel SH; Department of Pediatric oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Jazyk: angličtina
Zdroj: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2017 May; Vol. 33 (5), pp. 793-800. Date of Electronic Publication: 2017 Mar 27.
DOI: 10.1007/s00381-017-3372-7
Abstrakt: Purpose: Seeds of Nigella sativa (NS) are used to combat various disease conditions through their antibacterial effects. To evaluate the seeds' potential, we studied their effect on the prevention of febrile neutropenia (FN) in children with brain tumors.
Methods: A randomized pretest-post-test control group study including 80 children (2-18 years) with brain tumors undergoing chemotherapy were equally allocated into two groups. Intervention group received 5 g of NS seeds daily throughout treatment while controls received nothing. CBC with differentials, incidence of FN, and LOS were noted on each follow-up.
Results: The majority of children 38/40 (95%), of the intervention group, took the seeds for 3-9 consecutive months. Eight out of 372 (2.2%) FN episodes were experienced by children of intervention group compared to controls 63/327 (19.3%) (p = 0.001) and a shorter LOS (median = 2.5 days) vs 5 days in the control group (p = 0.006). Children in both groups belonged to almost same geographical area with similar socio-economic background. Weights of children were almost equal at diagnosis.
Conclusion: NS seeds showed a decrease in incidence of FN in children with brain tumors with shortening of subsequent LOS which may improve their outcome and thereby quality of life. Larger scale studies are needed to further evaluate the seeds' potential.
Databáze: MEDLINE
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