In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and Cytotoxic Study.
Autor: | Tekwu EM; Laboratory for Tuberculosis Research and Pharmacology, Biotechnology Centre, Nkolbisson, University of Yaoundé 1, Yaoundé, Cameroon; Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences, University of Ghana, PO Box LG581 Legon, Accra, Ghana., Bosompem KM; Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences, University of Ghana, PO Box LG581 Legon, Accra, Ghana., Anyan WK; Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences, University of Ghana, PO Box LG581 Legon, Accra, Ghana., Appiah-Opong R; Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences, University of Ghana, PO Box LG581 Legon, Accra, Ghana., Owusu KB; Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences, University of Ghana, PO Box LG581 Legon, Accra, Ghana., Tettey MD; Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences, University of Ghana, PO Box LG581 Legon, Accra, Ghana., Kissi FA; Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences, University of Ghana, PO Box LG581 Legon, Accra, Ghana., Appiah AA; Centre for Plant Medicine Research (CPMR), Akwapim, Mampong, Ghana., Penlap Beng V; Laboratory for Tuberculosis Research and Pharmacology, Biotechnology Centre, Nkolbisson, University of Yaoundé 1, Yaoundé, Cameroon., Nyarko AK; School of Pharmacy, College of Health Sciences, University of Ghana, Accra, Ghana. |
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Jazyk: | angličtina |
Zdroj: | Journal of parasitology research [J Parasitol Res] 2017; Vol. 2017, pp. 2583969. Date of Electronic Publication: 2017 Feb 28. |
DOI: | 10.1155/2017/2583969 |
Abstrakt: | Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for the search of novel antischistosomal compounds. This study investigated the anthelmintic activity of the stem bark and roots of Rauwolfia vomitoria against two life stages of Schistosoma mansoni . Both plant parts were found to be active against cercariae and adult worms. Within 2 h of exposure all cercariae were killed at a concentration range of 62.5-1000 µ g/mL and 250-1000 µ g/mL of R. vomitoria stem bark and roots, respectively. The LC Competing Interests: The authors declare that they have no competing interests |
Databáze: | MEDLINE |
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