Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin.

Autor:	Serebryannyy LA; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA leo.serebryannyy@nih.gov., Yemelyanov A; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Gottardi CJ; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., de Lanerolle P; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.
Jazyk:	angličtina
Zdroj:	Journal of cell science [J Cell Sci] 2017 May 15; Vol. 130 (10), pp. 1717-1729. Date of Electronic Publication: 2017 Mar 27.
DOI:	10.1242/jcs.199893
Abstrakt:	α-Catenin is an F-actin-binding protein widely recognized for its role in cell-cell adhesion. However, a growing body of literature indicates that α-catenin is also a nuclear protein. In this study, we show that α-catenin is able to modulate the sensitivity of cells to DNA damage and toxicity. Furthermore, nuclear α-catenin is actively recruited to sites of DNA damage. This recruitment occurs in a β-catenin-dependent manner and requires nuclear actin polymerization. These findings provide mechanistic insight into the WNT-mediated regulation of the DNA damage response and suggest a novel role for the α-catenin-β-catenin complex in the nucleus. Competing Interests: Competing interestsThe authors declare no competing or financial interests. (© 2017. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
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