Guidance on radiation dose limits for the lens of the eye: overview of the recommendations in NCRP Commentary No. 26.

Autor: Dauer LT; a Radiology & Medical Physics , Memorial Sloan Kettering Cancer Center , New York , NY , USA., Ainsbury EA; b Centre for Radiation, Chemical and Environmental Hazards (CRCE) , Public Health England , Oxford , UK., Dynlacht J; c Radiation Oncology , Indiana University School of Medicine , Indianapolis , IN , USA., Hoel D; d Public Health Services , Medical University of South Carolina , Charleston , SC , USA., Klein BEK; e Ophthalmology & Visual Sciences , University of Wisconsin-Madison , Madison , WI , USA., Mayer D; f Special Projects , Indian Point Energy Center , Buchanan , NY , USA., Prescott CR; g Wilmer Eye Institute , Johns Hopkins Medicine , Bel Air , MD , USA., Thornton RH; a Radiology & Medical Physics , Memorial Sloan Kettering Cancer Center , New York , NY , USA., Vano E; h Radiology , Complutense University , Madrid , Spain., Woloschak GE; i Radiation Oncology , Northwestern University , Chicago , IL , USA., Flannery CM; j Office of Nuclear Material Safety and Safeguards , U.S. Nuclear Regulatory Commission , Rockville , MD , USA., Goldstein LE; k Pathology & Laboratory Medicine , Boston University , Boston , MA , USA., Hamada N; l Nuclear Technology Research Center , Central Research Institute of Electric Power Industry , Tokyo , Japan., Tran PK; m Radiation Safety Program , Electric Power Research Institute , Palo Alto , CA , USA., Grissom MP; n National Council on Radiation Protection and Measurements , Bethesda , MD , USA., Blakely EA; o Life Sciences Division , Lawrence Berkeley National Laboratory , Berkeley , CA , USA.
Jazyk: angličtina
Zdroj: International journal of radiation biology [Int J Radiat Biol] 2017 Oct; Vol. 93 (10), pp. 1015-1023. Date of Electronic Publication: 2017 Apr 03.
DOI: 10.1080/09553002.2017.1304669
Abstrakt: Purpose: This review summarizes the conclusions and recommendations of the new National Council on Radiation Protection and Measurements (NCRP) Commentary No. 26 guidance on radiation dose limits for the lens of the eye. The NCRP addressed radiation protection principles in respect to the lens of the eye, discussed the current understanding of eye biology and lens effects, reviewed and evaluated epidemiology, and assessed exposed populations with the potential for significant radiation exposures to the lens while suggesting monitoring and protection practices.
Conclusions: Radiation-induced damage to the lens of the eye can include the loss of clarity resulting in opacification or clouding several years after exposure. The impact is highly dependent on the type of radiation, how the exposure of the lens was delivered, the genetic susceptibilities of the individual exposed, and the location of the opacity relative to the visual axis of the individual. The preponderance of epidemiological evidence suggests that lens damage could occur at lower doses than previously considered and the NCRP has determined that it is prudent to reduce the recommended annual lens of the eye occupational dose limit from an equivalent dose of 150 mSv to an absorbed dose of 50 mGy. Significant additional research is still needed in the following areas: comprehensive evaluation of the overall effects of ionizing radiation on the eye, dosimetry methodology and dose-sparing optimization techniques, additional high quality epidemiology studies, and a basic understanding of the mechanisms of cataract development.
Databáze: MEDLINE
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