Impact of bone marrow-derived mesenchymal stem cells on remodeling the lung injury induced by lipopolysaccharides in mice.

Autor:	Mohi El-Din MM; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt., Rashed LA; Biochemistry & Molecular Biology Department, Medicine Faculty, Cairo University, Cairo, Egypt; Biochemistry & Molecular Biology Department, Medicine Faculty, Cairo University, Cairo, Egypt., Mahmoud Haridy MA; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt., Khalil AM; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt., Mohamed Albadry MA; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
Jazyk:	angličtina
Zdroj:	Future science OA [Future Sci OA] 2017 Jan 17; Vol. 3 (1), pp. FSO162. Date of Electronic Publication: 2017 Jan 17 (Print Publication: 2017).
DOI:	10.4155/fsoa-2016-0036
Abstrakt:	Aim: This study evaluated the potential of bone marrow derived mesenchymal stem cells (MSCs) to regulate cytokines and remodel the lung induced by lipopolysaccharide (LPS; O-antigen). Materials & Methods: A group of mice (n = 21) was inoculated intraperitoneally with one dose 0.1 ml containing 0.025 mg LPS/mouse, and another treated intravenously with one dose of labeling bone marrow derived MSCs at 7.5 × 10 5 cell/mouse 4 h after LPS injection. All animals were sacrificed on the 1st, 7th and 14th days post-injection. Results: MSCs increased the level of IL-10 with suppression of TNF-α, decrease of collagen fibers and renewal of alveolar type I cells, together with lung tissue remodeling. Conclusion: MSCs were shown to modulate inflammatory cytokines (TNF-α and IL-10) and to differentiate into alveolar type I cells, which prevented fibrosis in lung tissue from LPS-treated mice. Competing Interests: Financial & competing interests disclosure The authors received financial aid from South Valley University, Qena, Egypt. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Databáze:	MEDLINE
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