Novel pyrazolo[1,5-a]pyridines as orally active EP 1 receptor antagonists: Synthesis, structure-activity relationship studies, and biological evaluation.
Autor: | Umei K; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Nishigaya Y; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Kondo A; Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., 4365-1, Kashiwabara, Hotaka, Azumino, Nagano 399-8304, Japan., Tatani K; Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., 4365-1, Kashiwabara, Hotaka, Azumino, Nagano 399-8304, Japan., Tanaka N; Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., 4365-1, Kashiwabara, Hotaka, Azumino, Nagano 399-8304, Japan., Kohno Y; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan., Seto S; Watarase Research Center, Discovery Research Headquarters, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Electronic address: shigeki.seto@mb.kyorin-pharm.co.jp. |
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Jazyk: | angličtina |
Zdroj: | Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 May 01; Vol. 25 (9), pp. 2635-2642. Date of Electronic Publication: 2017 Mar 14. |
DOI: | 10.1016/j.bmc.2017.03.003 |
Abstrakt: | Novel pyrazolo[1,5-a]pyridine derivatives were designed, synthesized and evaluated as orally active EP (Copyright © 2017 Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
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