| Autor: |
Iacangelo AL; Unit on Molecular and Cellular Neurobiology, NIMH, Bethesda, MD 20892., Fischer-Colbrie R, Koller KJ, Brownstein MJ, Eiden LE |
| Jazyk: |
angličtina |
| Zdroj: |
Endocrinology [Endocrinology] 1988 May; Vol. 122 (5), pp. 2339-41. |
| DOI: |
10.1210/endo-122-5-2339 |
| Abstrakt: |
Specific oligonucleotide priming of double-stranded DNA has been employed to sequence a porcine chromogranin A adrenomedullary cDNA. Porcine chromogranin A is more than 80% identical to human, bovine, and rat chromogranin A at its deduced N- and C-termini. A 49-amino acid region of the porcine molecule is 59-71% homologous to corresponding areas of rat, bovine, and human chromogranin A, and identical to the amino acid sequence of porcine pancreastatin. The sequence is preceded by an arginine at the N-terminus and followed by a GKR sequence at the C-terminus. Thus, porcine chromogranin A can serve as the precursor for pancreastatin, a polypeptide capable of inhibiting insulin release from the endocrine pancreas and acid secretion from parietal cells of the gut. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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