[Effectiveness of preventive treatment by Influenzinum in the winter period against the onset of influenza-like illnesses].

Autor:	Marinone C; Département de médecine générale, Aix-Marseille université, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France., Bastard M; Département de médecine générale, Aix-Marseille université, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France., Bonnet PA; Département de médecine générale, Aix-Marseille université, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France., Gentile G; Département de médecine générale, Aix-Marseille université, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France., Casanova L; Département de médecine générale, Aix-Marseille université, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France. Electronic address: ludovic.casanova@inserm.fr.
Jazyk:	francouzština
Zdroj:	Therapie [Therapie] 2017 Sep; Vol. 72 (4), pp. 465-474. Date of Electronic Publication: 2017 Feb 17.
DOI:	10.1016/j.therap.2016.12.011
Abstrakt:	Aim: In vitro Influenzinum induce a cellular change. We present the results of the first study examining the effectiveness of Influenzinum against influenza-like illnesses. Method: Retrospective cohort study during winter 2014-2015. After influenza epidemic, a self-assessment questionnaire was offered to patients presenting for a consultation. The primary endpoint was the declaration of an influenza-like illness. The exposed patients (treated by Influenzinum) were matched to two non-exposed patients (untreated) with a propensity score. A conditional logistic model expressed influenza-like illness risk reduction provided by the Influenzinum. Results: The cohort included 3514 patients recruited from 46 general practitioners. After matching, the treated group (n=2041) and the untreated group (n=482) did not differ on variables collected. Influenzinum preventive therapy does not significantly alter the likelihood of influenza-like illness (adjusted odds ratio=0,91 [0,62 to 1,35], p=0,64). Conclusion: Influenzinum preventive therapy did not appear effective in preventing influenza-like illness. (Copyright © 2017 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.)
Databáze:	MEDLINE
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