Linkage between mitochondrial genome alterations, telomere length and aging population.

Autor: Zole E; a Latvian Biomedical Research and Study Centre , Riga , Latvia.; b Faculty of Biology , University of Latvia , Riga , Latvia., Zadinane K; c Riga Stradins University , Riga , Latvia., Pliss L; a Latvian Biomedical Research and Study Centre , Riga , Latvia., Ranka R; a Latvian Biomedical Research and Study Centre , Riga , Latvia.; c Riga Stradins University , Riga , Latvia.
Jazyk: angličtina
Zdroj: Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis [Mitochondrial DNA A DNA Mapp Seq Anal] 2018 Apr; Vol. 29 (3), pp. 431-438. Date of Electronic Publication: 2017 Mar 24.
DOI: 10.1080/24701394.2017.1303490
Abstrakt: We studied telomere length (TL) and mitochondrial DNA (mtDNA) copy number variations in individuals from Latvian Caucasian population in different age groups. We showed a positive correlation between TL and mtDNA copy number in individuals of up to 90 years of age; however, this correlation was not observed in the 90-100 years age group. While TL shortened with age and mtDNA content decreased with increasing age, in this study it was observed that mtDNA copy number in nonagenarians was slightly higher than in the 60-89 years age group. The presence of heteroplasmy in the mtDNA HVS-I control region did not correlate with TL and mtDNA copy number. TL and mtDNA values also did not differ between mitochondrial haplogroups. In conclusion, while both TL and mtDNA are involved in the aging process and link between these cell components exists, nonagenarians may have differences in senescence-related pathways and systems, which may function as a protective mechanism that allows them to live longer.
Databáze: MEDLINE
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