The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features.

Autor:	Pabst T; Department of Medical Oncology, Inselspital Bern, Switzerland., Kortz L; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Germany., Fiedler GM; Institute of Clinical Chemistry, Inselspital Bern, Switzerland., Ceglarek U; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Germany., Idle JR; Hepatology Research Group, Department of Clinical Research, University of Bern, Switzerland., Beyoğlu D; Hepatology Research Group, Department of Clinical Research, University of Bern, Switzerland.
Jazyk:	angličtina
Zdroj:	BBA clinical [BBA Clin] 2017 Mar 08; Vol. 7, pp. 105-114. Date of Electronic Publication: 2017 Mar 08 (Print Publication: 2017).
DOI:	10.1016/j.bbacli.2017.03.002
Abstrakt:	Background: Early studies established that certain lipids were lower in acute myeloid leukemia (AML) cells than normal leukocytes. Because lipids are now known to play an important role in cell signaling and regulation of homeostasis, and are often perturbed in malignancies, we undertook a comprehensive lipidomic survey of plasma from AML patients at time of diagnosis and also healthy blood donors. Methods: Plasma lipid profiles were measured using three mass spectrometry platforms in 20 AML patients and 20 healthy blood donors. Data were collected on total cholesterol and fatty acids, fatty acid amides, glycerolipids, phospholipids, sphingolipids, cholesterol esters, coenzyme Q10 and eicosanoids. Results: We observed a depletion of plasma total fatty acids and cholesterol, but an increase in certain free fatty acids with the observed decline in sphingolipids, phosphocholines, triglycerides and cholesterol esters probably driven by enhanced fatty acid oxidation in AML cells. Arachidonic acid and precursors were elevated in AML, particularly in patients with high bone marrow (BM) or peripheral blasts and unfavorable prognostic risk. PGF2α was also elevated, in patients with low BM or peripheral blasts and with a favorable prognostic risk. A broad panoply of lipid classes is altered in AML plasma, pointing to disturbances of several lipid metabolic interconversions, in particular in relation to blast cell counts and prognostic risk. Conclusions: These data indicate potential roles played by lipids in AML heterogeneity and disease outcome. General Significance: Enhanced catabolism of several lipid classes increases prognostic risk while plasma PGF2α may be a marker for reduced prognostic risk in AML.
Databáze:	MEDLINE
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