Plasma ω-3 fatty acids in pregnancy are inversely associated with postpartum weight retention in a multiethnic Asian cohort.

Autor:	Loy SL; Departments of Reproductive Medicine.; Duke-NUS Medical School, Singapore., Ng MJH; Paediatrics and., Cheung YB; Center for Quantitative Medicine.; Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland., Godfrey KM; Medical Research Council Lifecourse Epidemiology Unit and.; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom., Calder PC; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom., Lek N; Paediatrics and.; Duke-NUS Medical School, Singapore., Yap F; Paediatrics and.; Duke-NUS Medical School, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Müller-Riemenschneider F; Saw Swee Hock School of Public Health and.; Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre, Berlin, Germany., Natarajan P; Departments of Obstetrics and Gynaecology and., Chong YS; Departments of Obstetrics and Gynaecology and.; Singapore Institute for Clinical Sciences and., Tan KH; Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore., Shek LP; Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore., Chong MF; Saw Swee Hock School of Public Health and.; Singapore Institute for Clinical Sciences and.; Clinical Nutrition Research Centre, Agency for Science, Technology and Research, Singapore; and., Chan JKY; Departments of Reproductive Medicine, jerrychan@duke-nus.edu.sg.; Duke-NUS Medical School, Singapore.
Jazyk:	angličtina
Zdroj:	The American journal of clinical nutrition [Am J Clin Nutr] 2017 May; Vol. 105 (5), pp. 1158-1165. Date of Electronic Publication: 2017 Mar 22.
DOI:	10.3945/ajcn.116.151258
Abstrakt:	Background: Studies have demonstrated associations between polyunsaturated fatty acids (PUFAs) and adiposity. It is unclear whether PUFAs in pregnancy have an effect on maternal weight retention after childbirth, which can contribute to long-term obesity. Objective: We examined the association of maternal plasma PUFAs in pregnancy with 18-mo postpartum weight retention (PPWR) in a multiethnic Asian cohort. Design: We studied pregnant women ( n = 653) recruited between June 2009 and September 2010 from a prospective cohort. At 26-28 wk of gestation, plasma phosphatidylcholine PUFA concentrations were measured and determined as percentages of total fatty acids (FAs). PPWR was calculated based on the difference between measured weight at the first antenatal clinic visit and at 18 mo postpartum. Results: The median retained weight of women was 0.90 kg (IQR: -1.40, 3.25) at 18 mo postpartum. Of 653 women, 544 women (83.3%) had PPWR of <5 kg and 109 (16.7%) had PPWR of ≥5 kg. In adjusted linear regression models, higher plasma eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and total ω-3 (n-3) PUFA concentrations were associated with lower PPWR [EPA: β = -0.62 kg/1% increase of total FAs (95% CI: -1.18, -0.05); DHA: β = -0.24 kg/1% increase (95% CI: -0.45, -0.02); total ω-3 PUFAs: β = -0.20 kg/1% increase (95% CI: -0.36, -0.03)], whereas a higher ratio of plasma ω-6-to-ω-3 PUFAs was associated with a higher PPWR [β = 0.21 kg/unit increase (95% CI: 0.05, 0.36)]. Conclusions: Higher plasma percentages of ω-3 PUFAs and a lower ratio of ω-6-to-ω-3 PUFAs in the late-second trimester of pregnancy are associated with less weight retention at 18 mo postpartum. This may offer an alternative strategy to assist postpartum weight reduction by increasing EPA and DHA status together with a decreased ratio of ω-6-to-ω-3 PUFA through diet or fish-oil supplementation during pregnancy. This study was registered at clinicaltrials.gov as NCT01174875. (© 2017 American Society for Nutrition.)
Databáze:	MEDLINE
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