Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection.

Autor:	Lake JE; Department of Medicine, University of Texas Health Science Center at Houston., Stanley TL; Department of Pediatrics, Harvard University School of Medicine and., Apovian CM; Departments of Medicine and.; Pediatrics, Boston University School of Medicine, Massachusetts., Bhasin S; Departments of Medicine and., Brown TT; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Capeau J; Department of Cell Biology and Metabolism, Univ-Paris 6, Inserm UMRS938, ICAN, Paris, France., Currier JS; Department of Medicine, University of California Los Angeles and., Dube MP; Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles., Falutz J; Department of Medicine, McGill University, Montreal, Quebec, Canada., Grinspoon SK; Department of Medicine, Harvard University School of Medicine, Boston, Massachusetts., Guaraldi G; Department of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy., Martinez E; Department of Medicine, University of Barcelona, Spain., McComsey GA; Department of Medicine and Pediatrics, Case Western University, Cleveland, Ohio; and., Sattler FR; Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles., Erlandson KM; Department of Medicine, University of Colorado School of Medicine, Aurora.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2017 May 15; Vol. 64 (10), pp. 1422-1429.
DOI:	10.1093/cid/cix178
Abstrakt:	Background: Obesity and lipohypertrophy are common in treated human immunodeficiency virus (HIV) infection and contribute to morbidity and mortality among HIV-infected adults on antiretroviral therapy (ART). Methods: We present a consensus opinion on the diagnosis, clinical consequences, and treatment of excess adiposity in adults with treated HIV infection. Results: Obesity and lipohypertrophy commonly occur among HIV-infected adults on ART and may have overlapping pathophysiologies and/or synergistic metabolic consequences. Traditional, HIV-specific, and ART-specific risk factors all contribute. The metabolic and inflammatory consequences of excess adiposity are critical drivers of non-AIDS events in this population. Although promising treatment strategies exist, further research is needed to better understand the pathophysiology and optimal treatment of obesity and lipohypertrophy in the modern ART era. Conclusions: Both generalized obesity and lipohypertrophy are prevalent among HIV-infected persons on ART. Aggressive diagnosis and management are key to the prevention and treatment of end-organ disease in this population and critical to the present and future health of HIV-infected persons. (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com)
Databáze:	MEDLINE
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