Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial.

Autor:	Chi DL; Department of Oral Health Sciences, University of Washington, Seattle, Wash., USA. dchi@uw.edu., Zegarra G; Department of Pediatric Dentistry, Universidad Alas Peruanas, Arequipa, Perú., Vasquez Huerta EC; Department of Pediatric Dentistry, Universidad Católica de Santa Maria, Arequipa, Perú., Castillo JL; Department of Oral Health Sciences, University of Washington, Seattle, Wash., USA; Department of Stomatology for Children and Adolescents, Universidad Peruana Cayetano Heredia, Lima, Peru., Milgrom P; Department of Oral Health Sciences, University of Washington, Seattle, Wash., USA., Roberts MC; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Wash., USA., Cabrera-Matta AR; Department of Stomatology for Children and Adolescents, Universidad Peruana Cayetano Heredia, Lima, Peru., Merino AP; Department of Stomatology for Children and Adolescents, Universidad Peruana Cayetano Heredia, Lima, Peru.
Jazyk:	angličtina
Zdroj:	Journal of dentistry for children (Chicago, Ill.) [J Dent Child (Chic)] 2016 Sep 15; Vol. 83 (3), pp. 152-160.
Abstrakt:	Purpose: To evaluate the efficacy of xylitol-sweetened milk as a caries-preventive strategy. Methods: In this nine-month prospective proof-of-principle trial, Peruvian schoolchildren were randomized to one of five different milk groups: (1) eight g of xylitol per 200 mL milk once per day; (2) four g of xylitol per 100 mL milk twice per day; (3) eight g of sorbitol per 200 mL milk once per day; (4) four g of sorbitol per 100 mL milk twice per day; or (5) eight g of sucrose per 200 mL milk once per day. The primary outcome was plaque mutans streptococci (MS) at nine months. A secondary outcome was caries incidence. We hypothesized that children in the xylitol groups would have a greater MS decline and lower caries incidence. Results: One hundred fifty-three children were randomized in the intent-to-treat analyses. Children receiving xylitol had a greater decline in MS than children receiving sucrose (P=0.02) but were not different from children receiving sorbitol (P=0.07). Dental caries incidence for xylitol once per day or twice per day was 5.3±3.4 and 4.3±4.0 surfaces, respectively, compared to sorbitol once per day, sorbitol twice per day, or sucrose (4.1±2.8, 3.7±4.2, and 3.2±3.4 surfaces, respectively). There were no differences in caries incidence between xylitol and sucrose (rate ratio [RR] = 1.51; 95 percent confidence interval [CI] = 0.88, 2.59; P=0.13) or between xylitol and sorbitol (RR = 1.28; 95 percent CI = 0.90, 1.83; P=0.16). Conclusion: Xylitol-sweetened milk significantly reduced mutans streptococci levels compared to sucrose-sweetened milk, but differences in caries incidence were not detected.
Databáze:	MEDLINE
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