Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.

Autor: Wyche TP; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States.; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin , Madison, Wisconsin 53705, United States., Ruzzini AC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States., Beemelmanns C; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States., Kim KH; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States., Klassen JL; Department of Bacteriology, University of Wisconsin , Madison, Wisconsin 53706, United States., Cao S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States., Poulsen M; Department of Bacteriology, University of Wisconsin , Madison, Wisconsin 53706, United States., Bugni TS; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin , Madison, Wisconsin 53705, United States., Currie CR; Department of Bacteriology, University of Wisconsin , Madison, Wisconsin 53706, United States., Clardy J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School , Boston, Massachusetts 02115, United States.
Jazyk: angličtina
Zdroj: Organic letters [Org Lett] 2017 Apr 07; Vol. 19 (7), pp. 1772-1775. Date of Electronic Publication: 2017 Mar 22.
DOI: 10.1021/acs.orglett.7b00545
Abstrakt: Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosynthetic gene cluster accounts for the observed structural diversity.
Databáze: MEDLINE
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