IL-6, TNF-α, IL-10, and nutritional status in pediatric patients with biliary atresia.

Autor:	Wilasco MIA; Hospital de Clínicas de Porto Alegre, Centro de Pesquisa, Laboratório Experimental de Hepatologia e Gastroenterologia, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Programa de Pós-graduação em Saúde da Criança e do Adolescente, Porto Alegre, RS, Brazil. Electronic address: ineswilasco@gmail.com., Uribe-Cruz C; Hospital de Clínicas de Porto Alegre, Centro de Pesquisa, Laboratório Experimental de Hepatologia e Gastroenterologia, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Programa de Pós-graduação em Gastroenterologia, Porto Alegre, RS, Brazil., Santetti D; Universidade do Vale do Rio dos Sinos (Unisinos), Faculdade de Nutrição, São Leopoldo, RS, Brazil., Fries GR; Hospital de Clínicas de Porto Alegre, Centro de Pesquisa, Laboratório de Psiquiatria Molecular, Porto Alegre, RS, Brazil., Dornelles CTL; Hospital de Clínicas de Porto Alegre, Departamento de Pediatria, Porto Alegre, RS, Brazil., Silveira TRD; Hospital de Clínicas de Porto Alegre, Centro de Pesquisa, Laboratório Experimental de Hepatologia e Gastroenterologia, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Programa de Pós-graduação em Saúde da Criança e do Adolescente, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Medicina, Programa de Pós-graduação em Gastroenterologia, Porto Alegre, RS, Brazil.
Jazyk:	angličtina
Zdroj:	Jornal de pediatria [J Pediatr (Rio J)] 2017 Sep - Oct; Vol. 93 (5), pp. 517-524. Date of Electronic Publication: 2017 Mar 19.
DOI:	10.1016/j.jped.2016.11.009
Abstrakt:	Objectives: The objective of the present study is to evaluate whether IL-6, TNF-α, IL-10 are associated with nutritional status in patients with cirrhosis secondary to biliary atresia and compare to healthy controls. Methods: The parameters used for nutritional assessment were the standard deviation scores of height-for-age and of triceps skinfold thickness-for-age. The severity of cirrhosis was evaluated using the Child-Pugh score and PELD/MELD. Serum cytokines were measured using Cytometric Bead Array flow cytometry. Results: IL-6, TNF-α, and IL-10 were significantly higher in the cirrhosis group when compared with the control group (2.4 vs. 0.24 (p<0.001), 0.21 vs. 0.14 (p=0.007), and 0.65 vs. 0.36 (p=0.004), respectively. IL-6 and IL-10 were positively correlated with disease severity (0.450 [p=0.001] and 0.410; [p=0.002], respectively). TNF-α did not show a significant correlation with disease severity (0.100; p=0.478). Regarding nutritional evaluation, IL-6 was negatively correlated with the standard deviation score of height-for-age (-0.493; p<0.001) and of triceps skinfold thickness-for-age (-0.503; p<0.001), respectively. IL-10 exhibited a negative correlation with the standard deviation score of height-for-age (-0.476; p<0.001) and the standard deviation score of triceps skinfold thickness-for-age (-0.388; p=0.004). TNF-α did not show any significance in both anthropometric parameters (-0.083 (p=0.555) and -0.161 (p=0.253). Conclusion: The authors suggest that, in patients with cirrhosis secondary to biliary atresia, IL-6 could be used as a possible supporting biomarker of deficient nutritional status and elevated IL-10 levels could be used as a possible early-stage supporting biomarker of deteriorating nutritional status. (Copyright © 2017 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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