Comparison of metabolic profiles and bioactivities of the leaves of three edible Congolese Hibiscus species.

Autor:	Kapepula PM; a Laboratory of Pharmacognosy , Center for Interdisciplinary Research on Medicines (CIRM), University of Liège , Liège , Belgium.; b Faculty of Pharmaceutical Sciences , Centre d'Etudes des Substances Naturelles d'Origine Végétale (CESNOV), University of Kinshasa , Kinshasa , Democratic Republic of Congo., Kabamba Ngombe N; b Faculty of Pharmaceutical Sciences , Centre d'Etudes des Substances Naturelles d'Origine Végétale (CESNOV), University of Kinshasa , Kinshasa , Democratic Republic of Congo., Tshisekedi Tshibangu P; a Laboratory of Pharmacognosy , Center for Interdisciplinary Research on Medicines (CIRM), University of Liège , Liège , Belgium.; b Faculty of Pharmaceutical Sciences , Centre d'Etudes des Substances Naturelles d'Origine Végétale (CESNOV), University of Kinshasa , Kinshasa , Democratic Republic of Congo., Tsumbu C; a Laboratory of Pharmacognosy , Center for Interdisciplinary Research on Medicines (CIRM), University of Liège , Liège , Belgium., Franck T; c Centre for Oxygen Research and Development (C.O.R.D.), University of Liège , Liège , Belgium., Mouithys-Mickalad A; c Centre for Oxygen Research and Development (C.O.R.D.), University of Liège , Liège , Belgium., Mumba D; d Faculty of Medicine , University of Kinshasa , Kinshasa , Democratic Republic of Congo.; e Department of Parasitolgy , Institute National de Recherches Biomédicales (INRB) , Kinshasa , Democratic Republic of Congo., Tshala-Katumbay D; d Faculty of Medicine , University of Kinshasa , Kinshasa , Democratic Republic of Congo.; f Department of Neurology , Oregon Health & Science University , Portland , USA., Serteyn D; c Centre for Oxygen Research and Development (C.O.R.D.), University of Liège , Liège , Belgium., Tits M; a Laboratory of Pharmacognosy , Center for Interdisciplinary Research on Medicines (CIRM), University of Liège , Liège , Belgium., Angenot L; a Laboratory of Pharmacognosy , Center for Interdisciplinary Research on Medicines (CIRM), University of Liège , Liège , Belgium., Kalenda PDT; b Faculty of Pharmaceutical Sciences , Centre d'Etudes des Substances Naturelles d'Origine Végétale (CESNOV), University of Kinshasa , Kinshasa , Democratic Republic of Congo., Frédérich M; a Laboratory of Pharmacognosy , Center for Interdisciplinary Research on Medicines (CIRM), University of Liège , Liège , Belgium.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2017 Dec; Vol. 31 (24), pp. 2885-2892. Date of Electronic Publication: 2017 Mar 21.
DOI:	10.1080/14786419.2017.1305382
Abstrakt:	Methanolic and dichloromethane extracts from the leaves of Congolese Hibiscus species were characterised by chromatographic and spectroscopic techniques and their in vitro biochemical activities against ROS production were evaluated in cellular models and on an enzyme, myeloperoxidase (MPO), involved in inflammation. Hibiscus acetosella has a chemical fingerprint different from Hibiscus cannabinus and Hibiscus sabdariffa both having similar fingerprints. Major compounds were polyphenols, represented mainly by caffeoyl-hydroxycitric acid for H. acetosella and neochlorogenic acid for the two other species. All extracts displayed high cellular antioxidant activity with IC 50 values ranging from 0.5 to 3 μg mL -1 using lucigenin on neutrophils. Dichloromethane extracts showed more efficient effects on extracellular ROS production and MPO activity. Antioxidant and anti-inflammatory activities of caffeoyl-hydroxycitric acid were significantly higher than those of neochlorogenic acid. The bioactivities of Hibiscus species were positively correlated with their phytochemical content and could justify their use as local nutraceutical resources and medicines.
Databáze:	MEDLINE
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