Functional Connectivity of the Pedunculopontine Nucleus and Surrounding Region in Parkinson's Disease.

Autor:	Jha A; Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, UK., Litvak V; Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.; Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, UK., Taulu S; I-LABS MEG Brain Imaging Center, University of Washington, Seattle, WA, USA.; Department of Physics, University of Washington, Seattle, WA, USA., Thevathasan W; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Hyam JA; Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK., Foltynie T; Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.; Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK., Limousin P; Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.; Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK., Bogdanovic M; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Zrinzo L; Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.; Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK., Green AL; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Aziz TZ; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Friston K; Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London, UK., Brown P; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.; MRC Brain Network Dynamics Unit, University of Oxford, Oxford, UK.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2017 Jan; Vol. 27 (1), pp. 54-67. Date of Electronic Publication: 2016 Nov 22.
DOI:	10.1093/cercor/bhw340
Abstrakt:	Deep brain stimulation of the pedunculopontine nucleus and surrounding region (PPNR) is a novel treatment strategy for gait freezing in Parkinson's disease (PD). However, clinical results have been variable, in part because of the paucity of functional information that might help guide selection of the optimal surgical target. In this study, we use simultaneous magnetoencephalography and local field recordings from the PPNR in seven PD patients, to characterize functional connectivity with distant brain areas at rest. The PPNR was preferentially coupled to brainstem and cingulate regions in the alpha frequency (8-12 Hz) band and to the medial motor strip and neighboring areas in the beta (18-33 Hz) band. The distribution of coupling also depended on the vertical distance of the electrode from the pontomesencephalic line: most effects being greatest in the middle PPNR, which may correspond to the caudal pars dissipata of the pedunculopontine nucleus. These observations confirm the crucial position of the PPNR as a functional node between cortical areas such as the cingulate/ medial motor strip and other brainstem nuclei, particularly in the dorsal pons. In particular they suggest a special role for the middle PPNR as this has the greatest functional connectivity with other brain regions. Competing Interests: Conflict of Interest: None declared.
Databáze:	MEDLINE
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