| Autor: |
Xiang M; Department of Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650500, China., Li R; Department of Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650500, China., Zhang Z; Department of Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650500, China., Song X; Department of Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650500, China. |
| Jazyk: |
čínština |
| Zdroj: |
Zhongguo fei ai za zhi = Chinese journal of lung cancer [Zhongguo Fei Ai Za Zhi] 2017 Mar 20; Vol. 20 (3), pp. 205-212. |
| DOI: |
10.3779/j.issn.1009-3419.2017.03.10 |
| Abstrakt: |
The high morbidity and mortality of non-small cell lung cancer (NSCLC) did influence the quality of life of tumor patients world-wide. There is an urgent need to develop new therapies that have high anti-tumor activity and low toxicity side effects. It is widely accepted that autophagy can play diverse roles in carcinogenesis, such as induces pro-death of lung cancer cells or helps the escape from cell death, making it become a proper anticancer target. It's believed that various monomers of Chinese traditional medicine closely correlates to anti-NSCLC activities, and that even could affect the acquired multiple drug resistance (MDR). Furthermore, autophagy might be the underling mechanisms which could play a role as the candidate targets of natural active compounds. Recent studies of terpenoids, alkaloid, dietary polyphenols, saponins and other active ingredients that extracted from a large variety of herbs suggest that different monomer compounds could either regulate the activity of pro-death autophagy or influence the level of protective autophagy of NSCLC cells, thus changing their drug sensitivity and cell viability. This paper aims to give a systemic description of the latest advances about natural compounds and their derivatives that involved in tumorigenesis of NSCLC via inducing the autophagy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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