Nanoskin® Subcutaneous Implant in Guinea Pigs.

Autor:	Kaminagakura KN; Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil., Sato SS; Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil., Sugino P; Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil., Santos DC; Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil., Kataki L; Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil., Padovani CR; Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil., Basmaji P; Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil., Schellini SA; Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil, and Instituto de Biociencias de Botucatu, Universidade Estadual Paulista, São Paulo State, Brazil.
Jazyk:	angličtina
Zdroj:	Ophthalmic plastic and reconstructive surgery [Ophthalmic Plast Reconstr Surg] 2018 Mar/Apr; Vol. 34 (2), pp. 136-139.
DOI:	10.1097/IOP.0000000000000893
Abstrakt:	Purpose: To evaluate the suitability of Nanoskin, a biomaterial derived from bacterial cellulose, as an alternate material for repairing the posterior lamellae of the eyelids. Methods: Forty guinea pigs received a fragment of Nanoskin subcutaneously in the dorsal region. The animals received Nanoskin (group 1) or Nanoskin coated with a gelatin layer (group 2). The animals were observed daily for over 7, 30, 90, or 180 days with the subcutaneous implants in place. The animals were euthanized at a designated time and the Nanoskin was removed for histologic, morphometric, and transmission electron microscopy evaluation. Results: The results were similar for both groups. The subcutaneously implanted Nanoskin resulted in good tissue integration, induced mild inflammation, and was surrounded by a delicate pseudocapsule. Conclusion: The good tissue integration of Nanoskin in study indicates that it may be a potential material for application as a substitute of posterior eyelid lamellar tissue. Further clinical studies are required to confirm the preliminary outcomes of this experimental study.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu