[The expression of claudins in colonic neoplasms].

Autor:	Oleinikova NA; Lomonosov Moscow State University, Moscow, Russia., Kharlova OA; Lomonosov Moscow State University, Moscow, Russia., Mal'kov PG; Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Postgraduate Education Ministry of Health of Russia, Moscow, Russia., Danilova NV; Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Postgraduate Education Ministry of Health of Russia, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Arkhiv patologii [Arkh Patol] 2017; Vol. 79 (1), pp. 28-35.
DOI:	10.17116/patol201779128-35
Abstrakt:	Aim: the evaluation of localization claudin-1, -3 and -4 types of cancer and colon polyps. Material and Methods: The study included 32 colon adenocarcinoma and 86 polyps. Antibody claudin-1; -3 and -4 were used as immunohistochemical markers in this study. Results: 84/118, 64/118, 52/118 reaction with claudin-1, claudin-3 and claudin-4 in cancer and colon polyps had a membrane localization, respectively. In 33 (27.9%) cases was found paradoxical reaction claudin-1; in 50 (42.4%) - a paradoxical reaction claudin-3 in 66 (55.9%) - a paradoxical reaction claudin-4. Among the paradoxical claudin reaction nuclear localization of marker was observed relatively rarely: claudin-3 in 2.5% cases of colon cancer; claudin-4 in 8.5% of colon polyps. Conclusion: Mislocalization claudin-3 to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.
Databáze:	MEDLINE
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