| Autor: |
Golimbet VE; I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia., Volel BA; I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia., Kopylov FY; I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia., Dolzhikov AV; I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia., Korovaitseva GI; I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia., Kasparov SV; I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia., Isaeva MI; I.M. Sechenov First Moscow Medical State University, ul. Trubetskaya 8 str. 2, 119992 Moscow, Russia. |
| Abstrakt: |
In a framework of search for early predictors of depression in patients with ischemic heart disease (IHD) we studied effect of molecular- genetic factors (polymorphism of brain-derived neirotrophic factor - BDNF), personality traits (anxiety, neuroticism), IHD severity, and psychosocial stressors on manifestations of depression in men with verified diagnosis of IHD. Severity of depression was assessed by Hamilton Depression Rating Scale 21-Item (HAMD 21), anxiety and neuroticism were evaluated by the Spielberger State-Trait Anxiety Inventory and "Big Five" questionnaire, respectively. It was shown that personal anxiety and ValVal genotype of BDNF gene appeared to be predictors of moderate and severe depression. |
