A simple and cost-effective HPLC-UV method for the detection of levetiracetam in plasma/serum of patients with epilepsy.
Autor: | Engelbrecht L; Clinical Pharmacokinetic Laboratory, School of Pharmacy (Pharmacology), North West University, Potchefstroom, South Africa., Grobler CJ; Department of Health Sciences, Vaal University of Technology, Vanderbijlpark, South Africa., Rheeders M; Clinical Pharmacokinetic Laboratory, School of Pharmacy (Pharmacology), North West University, Potchefstroom, South Africa. |
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Jazyk: | angličtina |
Zdroj: | Biomedical chromatography : BMC [Biomed Chromatogr] 2017 Oct; Vol. 31 (10). Date of Electronic Publication: 2017 Apr 20. |
DOI: | 10.1002/bmc.3969 |
Abstrakt: | A simple, fast and cost-effective method was developed and validated for the determination of levetiracetam (LEV) in plasma/serum of patients using high performance liquid chromatography (HPLC) with ultraviolet detection. The stability of LEV plasma/serum samples over time and in different blood collection tubes was evaluated. Serum/plasma samples were deproteinized by methanol spiked with the internal standard, gabapentin. HPLC was carried out on a Venusil XBP C (Copyright © 2017 John Wiley & Sons, Ltd.) |
Databáze: | MEDLINE |
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