Multiple myeloma associated with an Evan's syndrome.

Autor:	Bechir A; Department of Hematology, Farhat Hached Hospital, Sousse Tunisia., Haifa R; Department of Hematology, Farhat Hached Hospital, Sousse Tunisia., Nesrine BS; Department of Hematology, Farhat Hached Hospital, Sousse Tunisia., Emna B; Department of Hematology, Farhat Hached Hospital, Sousse Tunisia., Senda M; Department of Radiology, Farhat Hached Hospital, Sousse Tunisia., Asma A; Department of Radiology, Farhat Hached Hospital, Sousse Tunisia., Amina BB; Laboratory of biologic Hematology, Farhat Hached Hospital, Sousse Tunisia., Mrabet S; Departement of Nephrology, Sahloul Hospital, Sousse Tunisia., Yosra BY; Department of Hematology, Farhat Hached Hospital, Sousse Tunisia., Mondher K; Laboratory of biologic Hematology, Farhat Hached Hospital, Sousse Tunisia., Abderrahim K; Department of Hematology, Farhat Hached Hospital, Sousse Tunisia.
Jazyk:	angličtina
Zdroj:	The Pan African medical journal [Pan Afr Med J] 2016 Nov 01; Vol. 25, pp. 127. Date of Electronic Publication: 2016 Nov 01 (Print Publication: 2016).
DOI:	10.11604/pamj.2016.25.127.10750
Abstrakt:	Auto-immun events are rare in multiple myeloma (MM). Here, we report one MM case complicated by Evans syndrome (Autoimmun hemolytic anemia (AIHA) associated with thrombocytopenia). A 52-year-old man was admitted in nephrology department with severe anemia, renal insufficiency and hypergamma globulinemia. Laboratory exams showed acute hemolysis due to an IgG warm autoantibody. Serum electrophoresis revealed the presence of a monoclonal IgG protein and urinary M protein was 2g/day. A whole body CT-Scan showed osteolytic lesions of vertebral body of C5, D4, L3, L4 and the left iliac wing. The diagnosis of multiple myeloma and Evan's syndrome was made, we underwent chemotherapy by BTD (bortezomib-thalidomide-dexamethasone) and continuous corticosteroid therapy but unfortunately the patient died secondary of a Lactic acidosis. The relationship between MM and hemolysis remain unclear. Competing Interests: Authors declare that they have no Competing interests.
Databáze:	MEDLINE
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