Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats.

Autor: Freitas de Lima F; Faculty of Health Science, Federal University of Grande Dourados, PO Box 533, 79804-970 Dourados, Brazil. Electronic address: flfernando_@hotmail.com., Traesel GK; Faculty of Health Science, Federal University of Grande Dourados, PO Box 533, 79804-970 Dourados, Brazil., Menegati SE; Faculty of Biological and Environmental Sciences, Federal University of Grande Dourados, PO Box 533, 79804-970 Dourados, Brazil., Santos AC; Faculty of Health Science, Federal University of Grande Dourados, PO Box 533, 79804-970 Dourados, Brazil., Souza RI; Faculty of Health Science, Federal University of Grande Dourados, PO Box 533, 79804-970 Dourados, Brazil., de Oliveira VS; University Center of Grande Dourados, 79824-900 Dourados, Brazil., Sanjinez-Argandoña EJ; Faculty of Engineering, Federal University of Grande Dourados, PO Box 533, 79804-970 Dourados, Brazil., Cardoso CA; Course of Chemistry, State University of Mato Grosso do Sul, PO Box 351, 79804-970 Dourados, Brazil., Oesterreich SA; Faculty of Health Science, Federal University of Grande Dourados, PO Box 533, 79804-970 Dourados, Brazil., Vieira MD; Faculty of Agricultural Sciences, Federal University of Grande Dourados, PO Box 533, 79804-970 Dourados, Brazil.
Jazyk: angličtina
Zdroj: Food research international (Ottawa, Ont.) [Food Res Int] 2017 Jan; Vol. 91, pp. 11-17. Date of Electronic Publication: 2016 Nov 19.
DOI: 10.1016/j.foodres.2016.11.019
Abstrakt: Attalea phalerata Mart. ex Spreng., popularly known as "bacuri", is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407. For the acute toxicity, one single dose of the APO (2000mg/kg) was administered by gavage to five female rats. In the subacute toxicity, four different doses (125, 250, 500 and 1000mg/kg) of the APO were administered to male and female rats for 28 consecutive days. No deaths or behavioral changes were observed during both experiments as well as no changes in organ weights, hematological, histopathological parameters. The biochemical parameters showed changes in phosphatase alkaline and albumin levels, however these values are within the normal range for the species. A significant reduction in cholesterol and triglycerides was also observed in some of the animals treated with the APO. Therefore, the LD50 is higher than 2000mg/kg and the APO oil can be considered safe at the doses tested in rats. However, further assessments are required in order to proceed to clinical studies in humans.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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