Clinically distinct presentations of copper deficiency myeloneuropathy and cytopenias in a patient using excessive zinc-containing denture adhesive.

Autor: Cathcart SJ; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States., Sofronescu AG; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address: alina.sofronescu@unmc.edu.
Jazyk: angličtina
Zdroj: Clinical biochemistry [Clin Biochem] 2017 Aug; Vol. 50 (12), pp. 733-736. Date of Electronic Publication: 2017 Mar 10.
DOI: 10.1016/j.clinbiochem.2017.03.005
Abstrakt: Objectives: While copper deficiency has long been known to cause cytopenias, copper deficiency myeloneuropathy is a more recently described entity. Here, we present the case of two clinically distinct presentations of acquired copper deficiency syndromes secondary to excessive use of zinc-containing denture adhesive over five years: myeloneuropathy and severe macrocytic anemia and neutropenia.
Methods: Extensive laboratory testing and histologic evaluation of the liver and bone marrow, were necessary to rule out other disease processes and establish the diagnosis of copper deficiency.
Results: The initial presentation consisted of a myelopathy involving the posterior columns. Serum and urine copper were significantly decreased, and serum zinc was elevated. On second presentation (five years later), multiple hematological abnormalities were detected. Serum copper was again decreased, while serum zinc was elevated.
Conclusions: Zinc overload is a preventable cause of copper deficiency syndromes. This rare entity presented herein highlights the importance of patient, as well as provider, education.
(Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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