Two new sesquiterpene lactone glycosides from Cnicus benedictus.

Autor:	Peng Y; a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.; b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA., Jian Y; a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China., Zulfiqar A; b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA., Li B; a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China., Zhang K; a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.; b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA., Long F; a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.; b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA., Peng C; a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China., Cai X; a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China., Khan IA; a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.; b National Center for Natural Products Research, Division of Pharmacognosy, Department of BioMolecular Sciences , School of Pharmacy, University of Mississippi , University , MS , USA., Wang W; a TCM and Ethnomedicine Innovation & Development Laboratory , School of Pharmacy, Hunan University of Chinese Medicine , Changsha , Hunan , China.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2017 Oct; Vol. 31 (19), pp. 2211-2217. Date of Electronic Publication: 2017 Mar 13.
DOI:	10.1080/14786419.2017.1295239
Abstrakt:	Two new sesquiterpene lactone glycosides, namely melitensin 15-O-β-D-glucoside (1) and 11β,13-dihydrosalonitenolide 15-O-β-D-glucoside (2), along with eight known compounds (3-10) were isolated from the aerial part of Cnicus benedictus L. Their structures were elucidated from analyses of extensive spectroscopic data. Compounds 1-6 all possessed an α-methyl-γ-lactone moiety. Moreover, compound 5 exhibited moderate activity against the growth of Aspergillus fumigatus, with IC 50 values of 17.67 μg mL -1 .
Databáze:	MEDLINE
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