Anti-HLA-DQ antibodies are highly and independently related to the C1q-binding capacity of HLA antibodies.

Autor: Arreola-Guerra JM; Department of Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico., Morales-Buenrostro LE; Department of Nephrology-Mineral Metabolism, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico., Granados J; Department of Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico., Castelán N; Histocompatibility Laboratory, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico., de Santiago A; Histocompatibility Laboratory, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico., Arvizu A; Histocompatibility Laboratory, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico., Gonzalez-Tableros N; Histocompatibility Laboratory, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico., López M; Histocompatibility Laboratory, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico., Vilatobá M; Department of Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico., Alberú J; Department of Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Vasco de Quiroga 15, Colonia Belisario Domínguez, Sección XVI, Tlalpan, Mexico City 14080, Mexico. Electronic address: josefinaalberu@hotmail.com.
Jazyk: angličtina
Zdroj: Transplant immunology [Transpl Immunol] 2017 Mar; Vol. 41, pp. 10-16. Date of Electronic Publication: 2017 Mar 08.
DOI: 10.1016/j.trim.2017.02.003
Abstrakt: The complement-binding capacity of anti-HLA antibodies (HLAabs) is recognized as a key pathogenic factor. The aim of this study is to describe the patient characteristics associated to the presence of C1q+ as well as those of the Abs per se when associated to C1q binding.
Methodology: This is a cross-sectional, observational, descriptive study of patients with previous sensitizing factors and awaiting a kidney transplant (KT). We determined anti-HLA antibodies and their C1q binding capacity with the C1q assay.
Results: Among the 55 included patients, 26 (47.2%) had at least one C1q+ anti-HLAab. A previous transplant history, a greater number of HLAabs, a greater % of class I or class II PRA, the average MFI of all HLAabs, the MFI of the dominant HLAab and the HLAab antigenic specificities against HLA-B, -C and -DQ, all proved to be risk factors associated to the presence of C1q binding HLAabs (C1q+). In the total population, were detected 1268 HLAabs, 230 (18.1%) of which were C1q+. On multivariate analysis, both HLAabs against the HLA-DQ antigenic specificity (OR 9.82 95% CI 5.4-17.6, p<0.001) and the MFI documented by LABScreen®SAB (OR 1.2% CI 1.22-1.3, p<0.001), proved to be risk factors.
Conclusion: Anti-HLA-DQ antibodies and the MFI (LABScreen®SAB) are highly and independently related to the C1q-binding capacity of HLA antibodies.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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