Associations between long-term exposure to PM 2.5 component species and blood DNA methylation age in the elderly: The VA normative aging study.

Autor: Nwanaji-Enwerem JC; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: jnwanajienwerem@g.harvard.edu., Dai L; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Colicino E; Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA., Oulhote Y; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Di Q; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Kloog I; Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel., Just AC; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hou L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Vokonas P; VA Normative Aging Study, Veterans Affairs Boston Healthcare System, The Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Baccarelli AA; Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY, USA., Weisskopf MG; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Schwartz JD; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2017 May; Vol. 102, pp. 57-65. Date of Electronic Publication: 2017 Mar 09.
DOI: 10.1016/j.envint.2016.12.024
Abstrakt: Background: Long-term PM 2.5 exposure and aging have been implicated in multiple shared diseases; studying their relationship is a promising strategy to further understand the adverse impact of PM 2.5 on human health.
Objective: We assessed the relationship of major PM 2.5 component species (ammonium, elemental carbon, organic carbon, nitrate, and sulfate) with Horvath and Hannum DNA methylation (DNAm) age, two DNA methylation-based predictors of chronological age.
Methods: This analysis included 552 participants from the Normative Aging Study with multiple visits between 2000 and 2011 (n=940 visits). We estimated 1-year PM 2.5 species levels at participants' addresses using the GEOS-chem transport model. Blood DNAm-age was calculated using CpG sites on the Illumina HumanMethylation450 BeadChip. We fit linear mixed-effects models, controlling for PM 2.5 mass and lifestyle/environmental factors as fixed effects, with the adaptive LASSO penalty to identify PM 2.5 species associated with DNAm-age.
Results: Sulfate and ammonium were selected by the LASSO in the Horvath DNAm-age models. In a fully-adjusted multiple-species model, interquartile range increases in both 1-year sulfate (95%CI: 0.28, 0.74, P<0.0001) and ammonium (95%CI: 0.02, 0.70, P=0.04) levels were associated with at least a 0.36-year increase in Horvath DNAm-age. No PM 2.5 species were selected by the LASSO in the Hannum DNAm-age models. Our findings persisted in sensitivity analyses including only visits with 1-year PM 2.5 levels within US EPA national ambient air quality standards.
Conclusion: Our results demonstrate that sulfate and ammonium were most associated with Horvath DNAm-age and suggest that DNAm-age measures differ in their sensitivity to ambient particle exposures and potentially disease.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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