Outcome of young patients with rectal adenocarcinoma.

Autor:	Lino-Silva LS; Gastrointestinal Pathology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico., Salcedo-Hernández RA; Surgical Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico., Ruiz-García EB; Translational Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico., León-Takahashi AM; Surgical Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico., García-Pérez L; Surgical Oncology, Instituto Nacional de Cancerología (INCan), Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	Journal of gastrointestinal oncology [J Gastrointest Oncol] 2017 Feb; Vol. 8 (1), pp. 96-101.
DOI:	10.21037/jgo.2016.09.04
Abstrakt:	Background: There is an increase in the incidence of rectal carcinoma (RC) in young patients. Methods: We analyzed 175 patients with sporadic RC which were divided in two groups according their age: 24 patients ≤40 years and 151 patients >40 years and the two groups were compared in order to determine if the outcomes (especially overall 5-year survival) were different. Results: Overall 5-year survival was similar between groups (67.1% for patients over 40 years and 70.4% for those under 40 years, P=0.803). The only differences found were in some clinicopathologic features: patients <40 years showed more dissected lymph nodes (LNs) (21 vs . 15, P=0.035) and more LN metastasis (54.2% vs . 39.1%, P=0.048). In multivariate analysis factors associated with worse survival were incomplete resection and no use of neoadjuvant therapy. Age did not demonstrate prognostic value (P=0.077). Conclusions: RC in people ≤40 years demonstrated greater number of LN harvested and LN metastases but oncologic outcomes, especially 5-year overall survival, were similar between groups. Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
Databáze:	MEDLINE
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