Placental hormone profiles as predictors of preterm birth in twin pregnancy: A prospective cohort study.

Autor: Lim H; Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh Queen's Medical Research Institute, Edinburgh, United Kingdom., Powell S; Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh Queen's Medical Research Institute, Edinburgh, United Kingdom., Mcnamara HC; Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh Queen's Medical Research Institute, Edinburgh, United Kingdom., Howie AF; Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh Queen's Medical Research Institute, Edinburgh, United Kingdom., Doust A; Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh Queen's Medical Research Institute, Edinburgh, United Kingdom., Bowman ME; Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia., Smith R; Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia., Norman JE; Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh Queen's Medical Research Institute, Edinburgh, United Kingdom., Stock SJ; Tommy's Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh Queen's Medical Research Institute, Edinburgh, United Kingdom.; School of Women's and Infants' Health, The University of Western Australia at King Edward Memorial Hospital, Crawley Western Australia, Australia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2017 Mar 09; Vol. 12 (3), pp. e0173732. Date of Electronic Publication: 2017 Mar 09 (Print Publication: 2017).
DOI: 10.1371/journal.pone.0173732
Abstrakt: Objective: The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth.
Study Design: Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (<34 weeks; n = 8), preterm (<37 weeks; n = 40) and term (37+ weeks; n = 50) deliveries.
Results: No significant differences were found between preterm and term deliveries in either absolute hormone concentrations or ratios. Estimated hormone concentrations and ratios at 26 weeks did not appear to predict preterm delivery. Salivary and serum hormone concentrations were generally poorly correlated.
Conclusion: Our results suggest that serial progesterone, estradiol, estriol and corticotropin-releasing hormone measurements in saliva and serum are not robust biomarkers for preterm birth in twin pregnancies.
Databáze: MEDLINE
Externí odkaz: