Synthesis and antibacterial activities of some novel 17, 18-unsaturated carbonyl compounds derivated from josamycin.

Autor: Zhao ZH; a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica , Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing 100050 , China., Jin LL; a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica , Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing 100050 , China., Xu YP; a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica , Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing 100050 , China., Liu C; a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica , Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing 100050 , China., Wang AP; a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica , Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing 100050 , China., Lei PS; a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Department of Medicinal Chemistry, Institute of Materia Medica , Peking Union Medical College & Chinese Academy of Medical Sciences , Beijing 100050 , China.
Jazyk: angličtina
Zdroj: Journal of Asian natural products research [J Asian Nat Prod Res] 2017 Apr; Vol. 19 (4), pp. 358-387. Date of Electronic Publication: 2016 Sep 26.
DOI: 10.1080/10286020.2016.1194834
Abstrakt: Some novel josamycin derivatives bearing an arylalkyl-type side chain were designed and synthesized. By HWE or Wittig reaction, 16-aldehyde group of josamycin analogs were converted into unsaturated carbonyl compounds. They were evaluated for their in vitro antibacterial activities against a panel of respiratory pathogens. 8b and 8e exhibited comparable activities against a panel of respiratory pathogens, especially to resistant ones in the series of desmycarosyl josamycin analogs. Among of all the target molecules, 21 showed the best antibacterial activities.
Databáze: MEDLINE
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