Demographic and clinical correlates of HIV-1 RNA levels in antiretroviral therapy-naive adults attending a tertiary hospital in Jos, Nigeria.

Autor: Anejo-Okopi J; Department of Microbiology, University of Jos, Nigeria; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria., Abah IO; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria; Department of Pharmacy, Jos University Teaching Hospital, Nigeria., Barshep Y; Department of Zoology , University of Jos , Nigeria., Ebonyi AO; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria; Department of Pediatrics, University of Jos, Nigeria., Daniyam C; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria; Department of Medicine, University of Jos, Nigeria., Isa SE; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria; Department of Pediatrics, University of Jos, Nigeria., Simji G; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria; Department of Pediatrics, University of Jos, Nigeria., Oguche S; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria; Department of Medicine, University of Jos, Nigeria., Agaba P; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria; Department of Family Medicine, University of Jos, Nigeria., Lar P; Department of Microbiology , University of Jos , Nigeria., Agbaji O; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria; Department of Pediatrics, University of Jos, Nigeria., Idoko JA; AIDS Prevention Initiative in Nigeria, Jos University Teaching Hospital, Nigeria; Department of Pediatrics, University of Jos, Nigeria.
Jazyk: angličtina
Zdroj: Journal of virus eradication [J Virus Erad] 2017 Jan 01; Vol. 3 (1), pp. 51-55. Date of Electronic Publication: 2017 Jan 01.
Abstrakt: Background: Plasma HIV-RNA viral load (VL) of HIV-infected persons is an important prognostic factor in HIV management. We determined the VL among antiretroviral therapy (ART)-naive patients to identify the association between patients' demographic, clinical and laboratory characteristics with VL.
Method: A cross-sectional study of 224 ART-naive HIV-1-infected patients (≥15 years of age) accessing care at the Jos University Teaching Hospital AIDS Prevention Initiative in Nigeria ART treatment centre, from October 2010 to April 2011. A log-linear model was used to determine if VL was related to demographic and clinical variables.
Results: The patients had a median (interquartile range) age of 34 (28-41) years with females in the majority (59%). Females compared to males and pulmonary tuberculosis (PTB) co-infected compared to not co-infected patients had a significantly higher VL (14.9 log e versus 11.5 log e , P =0.003 and 11.31 log e versus 11.89 log e , P =0.047, respectively). VL tended to decrease with increasing CD4+ cell count levels in females, but remained relatively unchanged in males across all values of CD4+ cell counts. The difference (β) in the mean change in VL between males and females was log e 0.64 copies/mL, P =0.005.
Conclusion: In ART-naive HIV-1-infected patients in our setting, females had significantly higher VL and lower CD4+ cell count, at the same VL threshold, compared to males, and hence were more likely to be at a higher risk of rapid progression to AIDS. Therefore, gender-based strategies for early identification and engaging females into care are required in this setting to mitigate against rapid progression to AIDS.
Databáze: MEDLINE
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