Effect of microbial siderophores on mammalian non-malignant and malignant cell lines.

Autor: Gokarn K; Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, Mumbai, 400 002, India. karuna.gokarn@xaviers.edu.; Caius Research Laboratory, St. Xavier's College, Mumbai, 400 001, India. karuna.gokarn@xaviers.edu., Sarangdhar V; Caius Research Laboratory, St. Xavier's College, Mumbai, 400 001, India., Pal RB; Department of Microbiology, Sir Hurkisondas Nurrotumdas Medical Research Society, Mumbai, 400 002, India.
Jazyk: angličtina
Zdroj: BMC complementary and alternative medicine [BMC Complement Altern Med] 2017 Mar 09; Vol. 17 (1), pp. 145. Date of Electronic Publication: 2017 Mar 09.
DOI: 10.1186/s12906-017-1657-8
Abstrakt: Background: Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment.
Methods: In the present study, we have evaluated effect of three siderophores - exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay.
Results: These siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells.
Conclusions: Based on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies.
Databáze: MEDLINE
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