Community-Associated Staphylococcus aureus from Sub-Saharan Africa and Germany: A Cross-Sectional Geographic Correlation Study.

Autor: Ruffing U; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany., Alabi A; Centre de Recherches Médicales de Lambaréné (CERMEL), Albert Schweitzer Hospital, Lambaréné, Gabon., Kazimoto T; Ifakara Health Research and Development Centre (IHRDC), Dar es Salaam, Tanzania., Vubil DC; Manhiça Health Research Center, Manhiça, Manhiça, Mozambique., Akulenko R; Center for Bioinformatics, Saarland University, Saarbrücken, Germany., Abdulla S; Ifakara Health Research and Development Centre (IHRDC), Dar es Salaam, Tanzania., Alonso P; Manhiça Health Research Center, Manhiça, Manhiça, Mozambique.; Department of Public Health, University of Barcelona, Barcelona, Spain., Bischoff M; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany., Germann A; Fraunhofer Institute for Biomedical Engineering, St. Ingbert, Germany., Grobusch MP; Centre de Recherches Médicales de Lambaréné (CERMEL), Albert Schweitzer Hospital, Lambaréné, Gabon.; Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands., Helms V; Center for Bioinformatics, Saarland University, Saarbrücken, Germany., Hoffmann J; Division of Infectious Diseases and Travel Medicine, University of Freiburg, Freiburg, Germany., Kern WV; Division of Infectious Diseases and Travel Medicine, University of Freiburg, Freiburg, Germany., Kremsner PG; Centre de Recherches Médicales de Lambaréné (CERMEL), Albert Schweitzer Hospital, Lambaréné, Gabon.; Institute of Tropical Medicine, University of Tübingen, Deutsches Zentrum für Infektionsforschung, Tübingen, Germany., Mandomando I; Manhiça Health Research Center, Manhiça, Manhiça, Mozambique., Mellmann A; Institute of Hygiene, University Hospital Münster, Münster, Germany., Peters G; Institute of Medical Microbiology, University Hospital Münster, Münster, Germany., Schaumburg F; Institute of Medical Microbiology, University Hospital Münster, Münster, Germany., Schubert S; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany., Strauß L; Institute of Hygiene, University Hospital Münster, Münster, Germany., Tanner M; Ifakara Health Research and Development Centre (IHRDC), Dar es Salaam, Tanzania.; Swiss Tropical and Public Health Institute, Basel, Switzerland., Briesen HV; Fraunhofer Institute for Biomedical Engineering, St. Ingbert, Germany., Wende L; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany., Müller LV; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany., Herrmann M; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg, Germany. mathias.herrmann@uni-muenster.de.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2017 Mar 13; Vol. 7 (1), pp. 154. Date of Electronic Publication: 2017 Mar 13.
DOI: 10.1038/s41598-017-00214-8
Abstrakt: Clonal clusters and gene repertoires of Staphylococcus aureus are essential to understand disease and are well characterized in industrialized countries but poorly analysed in developing regions. The objective of this study was to compare the molecular-epidemiologic profiles of S. aureus isolates from Sub-Saharan Africa and Germany. S. aureus isolates from 600 staphylococcal carriers and 600 patients with community-associated staphylococcal disease were characterized by DNA hybridization, clonal complex (CC) attribution, and principal component (PCA)-based gene repertoire analysis. 73% of all CCs identified representing 77% of the isolates contained in these CCs were predominant in either African or German region. Significant differences between African versus German isolates were found for alleles encoding the accessory gene regulator type, enterotoxins, the Panton-Valentine leukocidin, immune evasion gene cluster, and adhesins. PCA in conjunction with silhouette analysis distinguished nine separable PCA clusters, with five clusters primarily comprising of African and two clusters of German isolates. Significant differences between S. aureus lineages in Africa and Germany may be a clue to explain the apparent difference in disease between tropical/(so-called) developing and temperate/industrialized regions. In low-resource countries further clinical-epidemiologic research is warranted not only for neglected tropical diseases but also for major bacterial infections.
Databáze: MEDLINE
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